Poly (anhydrides). 3. Poly (anhydrides) Based on Aliphatic—Aromatic Diacids

Abraham J. Domb, Carlos F. Gallardo, Robert Langer

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Poly (anhydrides) containing aliphatic and aromatic moieties, poly(ω-(p-carboxyphenoxy)alkanoic anhydride), of the structure -(COC6H40(CH2)„COO)n- (x = 1, 4, and 7) were synthesized by either melt or solution polymerization with molecular weights of up to 44600. These polymers displayed a zero-order hydrolytic degradation profile for 2–10 weeks. The longer the length of the alkanoic chain, the longer the degradation rate. Stability studies under anhydrous conditions showed that these polymers were stable in solid state for over 6 months at 25 °C but underwent reversible self-depolymerization in chloroform solution.

Original languageEnglish
Pages (from-to)3200-3204
Number of pages5
Issue number8
StatePublished - 1 Aug 1989
Externally publishedYes


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