Polarographic Oxidation of Diaminopyrimidines

D. Cohen, M. Koenigsbuch, M. Sprecher

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations


    The polarographic oxidation of 2, 5‐diaminopyrimidine (IV) and 4,5‐diaminopyrimidine (V) at the rotating Pt microelectrode in aqueous buffered solutions was studied. The effects of varying concentrations, temperature, pH, buffer concentration, rate of rotation of electrode and rate of scanning of potential were determined. The limiting currents are diffusion controlled and proportional to concentration up to 1 × 10−3 M for (IV) and 2 × 10−4 M for (V). The overall reaction is irreversible and probably involves two electrons per molecule to give an unstable product with a quinonimine structure. The dependence of E½ on pH in the anodic polarography of twelve more polyamino‐ and aminohydroxy‐pyrimidines was determined. Hückel type MO calculations were carried out for the pyrimidines and the energies calculated for the highest occupied MOs were correlated with E°½ values.

    Original languageEnglish
    Pages (from-to)615-630
    Number of pages16
    JournalIsrael Journal of Chemistry
    Issue number5
    StatePublished - 1968


    Dive into the research topics of 'Polarographic Oxidation of Diaminopyrimidines'. Together they form a unique fingerprint.

    Cite this