Point-of-care anti-CD19 chimeric antigen receptor T-cell therapy for relapsed/refractory follicular lymphoma

Shalev Fried, Eden Shkury, Orit Itzhaki, Inbal Sdayoor, Ronit Yerushalmi, Noga Shem-Tov, Ivetta Danylesko, Elad Jacoby, Roni Shouval, Meirav Kedmi, Ronit Marcus, Arnon Nagler, Avichai Shimoni, Abraham Avigdor

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Patients with relapsed/refractory follicular lymphoma (R/R-FL) often require multiple treatment lines. We performed a phase 1b/2 single-center clinical trial of autologous point-of-care anti-CD19 chimeric antigen receptor (CAR) T-cells in R/R-FL patients treated patients with ≥ 2 treatment lines. All 26 patients enrolled received CAR T-cell infusion at a median of 11 days after leukapheresis. Seventy-seven percent of patients had POD24. At enrollment, disease stage was III-IV in 85% of the patients, 77% had high-risk FLIPI score, and 77% had progressive disease. Grade III-IV cytokine release and immune effector cell-associated neurotoxicity syndromes occurred in 12% and 16% of the patients, respectively. Overall response rate at 1-month was 88%. The median follow-up was 15.4 months. One-year overall and progression-free survival were 100% and 63%, respectively. In conclusion, point-of-care CAR T-cell, manufactured within 11 days, induced a high response rate with an acceptable safety profile in patients with high-risk R/R-FL.

Original languageEnglish
Pages (from-to)1956-1963
Number of pages8
JournalLeukemia and Lymphoma
Issue number12
Early online date11 Aug 2023
StatePublished - Dec 2023

Bibliographical note

Publisher Copyright:
© 2023 Informa UK Limited, trading as Taylor & Francis Group.


RS was supported by the Memorial Sloan Kettering Cancer Center Core grant (P30 CA008748) from the National Institutes of Health/National Cancer Institute.

FundersFunder number
National Institutes of Health
National Cancer Institute


    • Chimeric antigen receptor
    • follicular lymphoma
    • point-of-care


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