Plurality-dependent risk of respiratory distress syndrome among very-low-birth-weight infants and antepartum corticosteroid treatment

Isaac Blickstein, Eric S. Shinwell, Ayala Lusky, Brian Reichman

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Objective: The purpose of this study was to determine the effect of antenatal corticosteroids on the incidence of respiratory distress syndrome in singleton infants and multiple infants who weigh <1500 g and are delivered at 24 to 32 weeks of gestation. Study design: The incidence of respiratory distress syndrome was established in 4754 singleton infants, 2460 twin infants, and 906 triplet infants. Results: The incidence of respiratory distress syndrome ranged from 58.2% among singleton infants who received a complete course of antenatal corticosteroid to 81.5% in triplets without any treatment. Complete treatment significantly reduced the incidence of respiratory distress syndrome, compared with partial or no treatment (odds ratio, 0.2-0.6). The adjusted risk for respiratory distress syndrome among infants who received a complete course of antenatal corticosteroids compared with singleton infants increased with plurality (odds ratio, 1.4 and 1.8 for twins and triplets, respectively). Conclusion: The effect of corticosteroids decreased with increasing plurality. Irrespective of plurality, a complete course of antenatal corticosteroids significantly reduced the incidence of respiratory distress syndrome, whereas partial treatment had the same effect as no treatment.

Original languageEnglish
Pages (from-to)360-364
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume192
Issue number2
DOIs
StatePublished - Feb 2005
Externally publishedYes

Bibliographical note

Funding Information:
Supported in part by the Israel Center for Disease Control and the Israeli Ministry of Health.

Keywords

  • Corticosteroid
  • Respiratory distress syndrome
  • Triplets
  • Twins

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