Platelet activating factor induces nerve growth factor production by rat astrocytes

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    Abstract

    During the course of brain injury and inflammation there is an enhanced secretion of neurotrophic substances. We have examined the effect of platelet activating factor (PAF), which has been associated with various pathological conditions in the central nervous system, on the secretion of nerve growth factor (NGF) by astrocytes. Enriched cultures of rat cortical astrocytes were treated with various concentrations of PAF for different periods of time. PAF induced a dose-dependent increase in NGF secretion, the maximal increase of 120% obtained with 50 nM PAF after 48 h of treatment. This effect was blocked by the specific antagonist WEB 2086 and was not related to a proliferative response of the cells to PAR Concomitant treatment of the cells with PAF and tumor necrosis factor-α resulted in a synergistic increase in NGF secretion. These results indicate that PAF may provide a neurotrophic signal to injured neurons and may cooperate with TNF-α in this effect.

    Original languageEnglish
    Pages (from-to)5-8
    Number of pages4
    JournalNeuroscience Letters
    Volume186
    Issue number1
    DOIs
    StatePublished - 15 Feb 1995

    Bibliographical note

    Funding Information:
    Supported in part by the Harriet-Aviv

    Keywords

    • Astrocytes
    • Brain trauma
    • Nerve growth factor
    • Platelet activating factor
    • Tumor necrosis factor-α

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