Plasmonic nanoparticle interaction with cell membrane for diagnostic applications

Sumana Das, Akshata Arikady, Ramakrishna Vasireddi, Krishna Harika Villa, Manish C. Konnur, Gopalkrishna M. Hegde, D. Roy Mahapatra

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Optofluidic schemes of inhibition, transport and activation by carrier molecules through cell membrane have interesting applications. Through plasmonic excitation of nanoparticles integrated in microfluidic channel, we observe cell membrane structural changes. Related phenomena are studied in situ in a microfluidic channel via fluorescence imaging. Detailed analysis is carried out to understand the possible application of this scheme in optically induced transport and expression of cell membrane protein. Optical properties of the cells undergoing plasmonic transport are monitored and correlated to cell expression assay. Plasmonic charge transport and optical transmission are measured in the microfluidic lab-on-chip along with in-situ imaging.

Original languageEnglish
Title of host publicationFrontiers in Biological Detection
Subtitle of host publicationFrom Nanosensors to Systems VII
EditorsBrian T. Cunningham, Benjamin L. Miller, Philippe M. Fauchet
ISBN (Electronic)9781628414004
StatePublished - 2015
Externally publishedYes
EventFrontiers in Biological Detection: From Nanosensors to Systems VII - San Francisco, United States
Duration: 7 Feb 2015 → …

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceFrontiers in Biological Detection: From Nanosensors to Systems VII
Country/TerritoryUnited States
CitySan Francisco
Period7/02/15 → …

Bibliographical note

Publisher Copyright:
© 2015 SPIE.


  • Binding
  • Cell membrane
  • Detection
  • Hydrodynamic
  • Lab-onchip
  • Nanoparticle
  • Optical transmission
  • Plasmon


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