Plasmonic-based Raman sensor for ultra-sensitive detection of pharmaceutical waste

Mohamed Hamode, Alon Krause, Maria Shehadeh, Bruria Schmerling, Tchiya Zar, Iddo Pinkas, David Zitoun, Adi Salomon

Research output: Contribution to journalArticlepeer-review


Pharmaceutical waste and contaminants pose a significant global concern for water and food safety. The detection of piperidine, a common residue in drug and supplement synthesis, is critical due to its toxic nature to both humans and animals. In this study, we develop a plasmonic-based detector for surface enhanced Raman scattering (SERS) measurements. The plasmonic device is composed of triangular cavities, milled in silver thin film, and protected by a 5 nm SiO2 layer. Due to the confined and enhanced electromagnetic field, remarkable sensitivity to piperidine with a concentration of 10−8 M in water is achieved. Despite the relatively small polarizability of piperidine, high sensitivity is observed even when using a low numerical aperture of 0.3, attributed to the directional scattering from our plasmonic device. Thus, it offers a cost-effective alternative to traditional high numerical aperture used in SERS, and the ability to use a portable Raman device for a cheaper and faster analysis.

Original languageEnglish
Pages (from-to)2083-2090
Number of pages8
JournalEnvironmental Science: Nano
Issue number5
StatePublished - 11 Mar 2024

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© 2024 The Royal Society of Chemistry.


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