Abstract
The signaling pathway directly controlling the maintenance of adult glutamatergic synapses has not been well understood. Planar cell polarity (PCP) signaling components were recently shown to play essential roles in the formation of glutamatergic synapses. Here, we show that they are localized in the adult synapses and are essential for their maintenance. Synapse loss at early stages of Alzheimer's disease is thought to be induced by β-amyloid (Aβ) pathology. We found that oligomeric Aβ binds to Celsr3 and assists Vangl2 in disassembling synapses. Moreover, a Wnt receptor and regulator of PCP signaling, Ryk, is also required for Aβ-induced synapse loss. In the 5XFAD mouse model of Alzheimer's disease, Ryk conditional knockout or a function-blocking monoclonal Ryk antibody protected synapses and preserved cognitive function. We propose that tipping of the fine balance of Wnt/PCP signaling components in glutamatergic synapses may cause synapse degeneration in neurodegenerative disorders with Aβ pathology.
Original language | English |
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Article number | eabh2307 |
Journal | Science advances |
Volume | 7 |
Issue number | 34 |
DOIs | |
State | Published - Aug 2021 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2021 The Authors.
Funding
Funders | Funder number |
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National Institute of Mental Health | R01MH116667 |
National Institute of Neurological Disorders and Stroke | P30NS047101 |