PLACEBO-CONTROLLED TRIAL OF TOPICAL INTERFERON IN LABIAL AND GENITAL HERPES

Marek Glezerman; Vered Cohen; Moshe Movshovitz; Jacob Shoham; Eitan Lunenfeld; Israel Sarov; Thomas Doerner; Michel Revel

doi:10.1016/s0140-6736(88)92723-7

PLACEBO-CONTROLLED TRIAL OF TOPICAL INTERFERON IN LABIAL AND GENITAL HERPES

Marek Glezerman, Vered Cohen, Moshe Movshovitz, Jacob Shoham, Eitan Lunenfeld, Israel Sarov, Thomas Doerner, Michel Revel

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Abstract

The efficacy of topical interferon-β (IFN-β) treatment was assessed in 25 patients with herpes of the lips or genitals who completed a 2-year follow-up in a double-blind placebo-controlled trial. IFN-β gel (10⁵ U/g) 4 times daily (about 2 × 10⁴ U) applied locally during eruptions (about 10 days) reduced the mean number of recurrences (p<0·007) and the duration of eruptions (p <0·007): in the placebo group these indices did not change significantly. Reduction of symptoms and severity was noted in 11 of 12 patients on IFN-β and in only 1 on placebo. No important side-effects were recorded. Topical IFN-β may therefore be advantageous as a time-limited local treatment of recurrent herpes simplex virus infections of the genitals and lips.

Original language	English
Pages (from-to)	150-152
Number of pages	3
Journal	The Lancet
Volume	331
Issue number	8578
DOIs	https://doi.org/10.1016/s0140-6736(88)92723-7
State	Published - 23 Jan 1988
Externally published	Yes

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10.1016/s0140-6736(88)92723-7

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title = "PLACEBO-CONTROLLED TRIAL OF TOPICAL INTERFERON IN LABIAL AND GENITAL HERPES",

abstract = "The efficacy of topical interferon-β (IFN-β) treatment was assessed in 25 patients with herpes of the lips or genitals who completed a 2-year follow-up in a double-blind placebo-controlled trial. IFN-β gel (105 U/g) 4 times daily (about 2 × 104 U) applied locally during eruptions (about 10 days) reduced the mean number of recurrences (p<0·007) and the duration of eruptions (p <0·007): in the placebo group these indices did not change significantly. Reduction of symptoms and severity was noted in 11 of 12 patients on IFN-β and in only 1 on placebo. No important side-effects were recorded. Topical IFN-β may therefore be advantageous as a time-limited local treatment of recurrent herpes simplex virus infections of the genitals and lips.",

author = "Marek Glezerman and Vered Cohen and Moshe Movshovitz and Jacob Shoham and Eitan Lunenfeld and Israel Sarov and Thomas Doerner and Michel Revel",

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AU - Glezerman, Marek

AU - Cohen, Vered

AU - Movshovitz, Moshe

AU - Shoham, Jacob

AU - Lunenfeld, Eitan

AU - Sarov, Israel

AU - Doerner, Thomas

AU - Revel, Michel

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AB - The efficacy of topical interferon-β (IFN-β) treatment was assessed in 25 patients with herpes of the lips or genitals who completed a 2-year follow-up in a double-blind placebo-controlled trial. IFN-β gel (105 U/g) 4 times daily (about 2 × 104 U) applied locally during eruptions (about 10 days) reduced the mean number of recurrences (p<0·007) and the duration of eruptions (p <0·007): in the placebo group these indices did not change significantly. Reduction of symptoms and severity was noted in 11 of 12 patients on IFN-β and in only 1 on placebo. No important side-effects were recorded. Topical IFN-β may therefore be advantageous as a time-limited local treatment of recurrent herpes simplex virus infections of the genitals and lips.

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PLACEBO-CONTROLLED TRIAL OF TOPICAL INTERFERON IN LABIAL AND GENITAL HERPES

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