PKCd, a member of the novel PKC family, has been widely implicated as mediator of apoptosis in response to phorbol esters and chemotherapeutic agents, and it is differentially expressed in various human cancer types. A characteristic of PKCd is that it is regulated by tyrosine phosphorylation, and in some cases this post-translational modification seems to be essential for the response to stimuli. PKCd may be an attractive target for cancer therapeutics.
|Original language||American English|
|Title of host publication||Protein Kinase C in Cancer Signaling and Therapy|
|Editors||Marcelo G. Kazanietz|
|State||Published - 2010|
|Name||Current Cancer Research|