Picosecond absorption relaxation measured with nanosecond laser photoacoustics

Amos Danielli, Christopher P. Favazza, Konstantin Maslov, Lihong V. Wang

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Picosecond absorption relaxation-central to many disciplines-is typically measured by ultrafast (femtosecond or picosecond) pump-probe techniques, which however are restricted to optically thin and weakly scattering materials or require artificial sample preparation. Here, we developed a reflection-mode relaxation photoacoustic microscope based on a nanosecond laser and measured picosecond absorption relaxation times. The relaxation times of oxygenated and deoxygenated hemoglobin molecules, both possessing extremely low fluorescence quantum yields, were measured at 576 nm. The added advantages in dispersion susceptibility, laser-wavelength availability, reflection sensing, and expense foster the study of natural-including strongly scattering and nonfluorescent-materials.

Original languageEnglish
Article number163701
JournalApplied Physics Letters
Volume97
Issue number16
DOIs
StatePublished - 18 Oct 2010
Externally publishedYes

Bibliographical note

Funding Information:
This work was sponsored in part by National Institutes of Health under Grant Nos. R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, and 5P60 DK02057933. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

Funding

This work was sponsored in part by National Institutes of Health under Grant Nos. R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, and 5P60 DK02057933. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

FundersFunder number
National Institutes of HealthR01 EB000712, R01 EB008085, R01 CA134539, 5P60 DK02057933, U54 CA136398

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