Picosecond absorption relaxation measured with nanosecond laser photoacoustics

Amos Danielli; Christopher P. Favazza; Konstantin Maslov; Lihong V. Wang

doi:10.1063/1.3500820

Picosecond absorption relaxation measured with nanosecond laser photoacoustics

Amos Danielli, Christopher P. Favazza, Konstantin Maslov, Lihong V. Wang

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42 Scopus citations

Abstract

Picosecond absorption relaxation-central to many disciplines-is typically measured by ultrafast (femtosecond or picosecond) pump-probe techniques, which however are restricted to optically thin and weakly scattering materials or require artificial sample preparation. Here, we developed a reflection-mode relaxation photoacoustic microscope based on a nanosecond laser and measured picosecond absorption relaxation times. The relaxation times of oxygenated and deoxygenated hemoglobin molecules, both possessing extremely low fluorescence quantum yields, were measured at 576 nm. The added advantages in dispersion susceptibility, laser-wavelength availability, reflection sensing, and expense foster the study of natural-including strongly scattering and nonfluorescent-materials.

Original language	English
Article number	163701
Journal	Applied Physics Letters
Volume	97
Issue number	16
DOIs	https://doi.org/10.1063/1.3500820
State	Published - 18 Oct 2010
Externally published	Yes

Bibliographical note

Funding Information:
This work was sponsored in part by National Institutes of Health under Grant Nos. R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, and 5P60 DK02057933. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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Picosecond absorption relaxation measured with nanosecond laser photoacoustics

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