Physiological Networks: Towards Systems Physiology

Ronny P Bartsch, Amir Bashan, Jan W Kantelhardt, Shlomo Havlin, Plamen Ch Ivanov

Research output: Contribution to journalMeeting Abstractpeer-review


The human organism is an integrated network where complex physiologic systems, each with its own regulatory mechanisms, continuously interact, and where failure of one system can trigger a breakdown of the entire network. Identifying and quantifying dynamical networks of diverse systems with different types of interactions is a challenge. Here, we develop a framework to probe interactions among diverse systems, and we identify a physiologic network. We find that each physiologic state is characterized by a specific network structure, demonstrating a robust interplay between network topology and function. Across physiologic states the network undergoes topological transitions associated with fast reorganization of physiologic interactions on time scales of a few minutes, indicating high network flexibility in response to perturbations. The proposed system-wide integrative approach may facilitate new dimensions to the field of systems physiology.
Original languageEnglish
Article numberB54.00012
Journal Bulletin of the American Physical Society
Issue number1
StatePublished - 27 Feb 2012

Bibliographical note

Place of conference:Boston, Massachusetts


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