Photovoltaic restoration of high visual acuity in rats with retinal degeneration

H. Lorach; G. Goetz; Y. Mandel; R. Smith; D. Boinagrov; X. Lei; R. Dalal; P. Huie; T. Kamins; J. Harris; K. Mathieson; A. Sher; D. Palanker

doi:10.1109/ner.2015.7146606

Photovoltaic restoration of high visual acuity in rats with retinal degeneration

H. Lorach
, G. Goetz
, Y. Mandel
, R. Smith
, D. Boinagrov
, X. Lei
, R. Dalal
, P. Huie
, T. Kamins
, J. Harris
, K. Mathieson
, A. Sher
, D. Palanker

Stanford University
University of California at Santa Cruz
University of Strathclyde

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Patients with retinal degeneration lose sight due to gradual demise of photoreceptors. Electrical stimulation of the surviving retinal neurons provides an alternative route for delivery of visual information. We developed subretinal photovoltaic arrays to convert pulsed light into bi-phasic pulses of current to stimulate the nearby inner retinal neurons. Bright pulsed illumination is provided by image projection from video goggles and avoids photophobic effects by using near-infrared (NIR, 880-915nm) light. Experiments in-vitro and in-vivo demonstrate that the network-mediated retinal stimulation preserves many features of natural vision, such as flicker fusion, adaptation to static images, and most importantly, high spatial resolution. Our implants with 70μm pixels restored visual acuity to half of the normal level in rats with retinal degeneration. Ease of implantation and tiling of these wireless arrays to cover a large visual field, combined with their high resolution opens the door to highly functional restoration of sight.

Original language	English
Title of host publication	2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015
Publisher	IEEE Computer Society
Pages	248-251
Number of pages	4
ISBN (Electronic)	9781467363891
DOIs	https://doi.org/10.1109/ner.2015.7146606
State	Published - 1 Jul 2015
Externally published	Yes
Event	7th International IEEE/EMBS Conference on Neural Engineering, NER 2015 - Montpellier, France Duration: 22 Apr 2015 → 24 Apr 2015

Publication series

Name	International IEEE/EMBS Conference on Neural Engineering, NER
Volume	2015-July
ISSN (Print)	1948-3546
ISSN (Electronic)	1948-3554

Conference

Conference	7th International IEEE/EMBS Conference on Neural Engineering, NER 2015
Country/Territory	France
City	Montpellier
Period	22/04/15 → 24/04/15

Bibliographical note

Publisher Copyright:
© 2015 IEEE.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 7 Affordable and Clean Energy

Access to Document

10.1109/ner.2015.7146606

Cite this

Lorach, H., Goetz, G., Mandel, Y., Smith, R., Boinagrov, D., Lei, X., Dalal, R., Huie, P., Kamins, T., Harris, J., Mathieson, K., Sher, A., & Palanker, D. (2015). Photovoltaic restoration of high visual acuity in rats with retinal degeneration. In 2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015 (pp. 248-251). Article 7146606 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2015-July). IEEE Computer Society. https://doi.org/10.1109/ner.2015.7146606

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title = "Photovoltaic restoration of high visual acuity in rats with retinal degeneration",

abstract = "Patients with retinal degeneration lose sight due to gradual demise of photoreceptors. Electrical stimulation of the surviving retinal neurons provides an alternative route for delivery of visual information. We developed subretinal photovoltaic arrays to convert pulsed light into bi-phasic pulses of current to stimulate the nearby inner retinal neurons. Bright pulsed illumination is provided by image projection from video goggles and avoids photophobic effects by using near-infrared (NIR, 880-915nm) light. Experiments in-vitro and in-vivo demonstrate that the network-mediated retinal stimulation preserves many features of natural vision, such as flicker fusion, adaptation to static images, and most importantly, high spatial resolution. Our implants with 70μm pixels restored visual acuity to half of the normal level in rats with retinal degeneration. Ease of implantation and tiling of these wireless arrays to cover a large visual field, combined with their high resolution opens the door to highly functional restoration of sight.",

author = "H. Lorach and G. Goetz and Y. Mandel and R. Smith and D. Boinagrov and X. Lei and R. Dalal and P. Huie and T. Kamins and J. Harris and K. Mathieson and A. Sher and D. Palanker",

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doi = "10.1109/ner.2015.7146606",

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Lorach, H, Goetz, G, Mandel, Y, Smith, R, Boinagrov, D, Lei, X, Dalal, R, Huie, P, Kamins, T, Harris, J, Mathieson, K, Sher, A & Palanker, D 2015, Photovoltaic restoration of high visual acuity in rats with retinal degeneration. in 2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015., 7146606, International IEEE/EMBS Conference on Neural Engineering, NER, vol. 2015-July, IEEE Computer Society, pp. 248-251, 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015, Montpellier, France, 22/04/15. https://doi.org/10.1109/ner.2015.7146606

Photovoltaic restoration of high visual acuity in rats with retinal degeneration. / Lorach, H.; Goetz, G.; Mandel, Y. et al.
2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015. IEEE Computer Society, 2015. p. 248-251 7146606 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2015-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Patients with retinal degeneration lose sight due to gradual demise of photoreceptors. Electrical stimulation of the surviving retinal neurons provides an alternative route for delivery of visual information. We developed subretinal photovoltaic arrays to convert pulsed light into bi-phasic pulses of current to stimulate the nearby inner retinal neurons. Bright pulsed illumination is provided by image projection from video goggles and avoids photophobic effects by using near-infrared (NIR, 880-915nm) light. Experiments in-vitro and in-vivo demonstrate that the network-mediated retinal stimulation preserves many features of natural vision, such as flicker fusion, adaptation to static images, and most importantly, high spatial resolution. Our implants with 70μm pixels restored visual acuity to half of the normal level in rats with retinal degeneration. Ease of implantation and tiling of these wireless arrays to cover a large visual field, combined with their high resolution opens the door to highly functional restoration of sight.

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Lorach H, Goetz G, Mandel Y, Smith R, Boinagrov D, Lei X et al. Photovoltaic restoration of high visual acuity in rats with retinal degeneration. In 2015 7th International IEEE/EMBS Conference on Neural Engineering, NER 2015. IEEE Computer Society. 2015. p. 248-251. 7146606. (International IEEE/EMBS Conference on Neural Engineering, NER). doi: 10.1109/ner.2015.7146606

Photovoltaic restoration of high visual acuity in rats with retinal degeneration

Abstract

Publication series

Conference

Bibliographical note

UN SDGs

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