Photothermic treatment of pigmented B16 melanoma using a broadband pulsed light delivery system

Genady Kostenich; Tatyana Babushkina; Zvi Malik; Arie Orenstein

doi:10.1016/S0304-3835(00)00508-5

Photothermic treatment of pigmented B16 melanoma using a broadband pulsed light delivery system

Genady Kostenich, Tatyana Babushkina, Zvi Malik, Arie Orenstein

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Pulsed photothermic treatment (PTT) of pigmented B16 mice melanoma tumors was carried out using a Photodyne(®) incoherent light delivery system. Tumor heating with average temperature of 41-44°C was observed during broadband photoirradiation (600-800 nm) at light doses of 60-120 J/cm² delivered using 0.6 J/cm² pulses (2 ms) at 1 Hz repetition rate. Electron microscopy of tumor samples revealed pronounced structural changes in microvasculature and melanosomes. Pulsed PTT caused damage to endothelial cells and vascular walls, swelling of mitochondria and melanosomal disruption without nuclear alteration. Significant tumor response with necrosis formation followed by tumor regression was observed by a tumor growth study after PTT at 120 J/cm². (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	161-168
Number of pages	8
Journal	Cancer Letters
Volume	157
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(00)00508-5
State	Published - 1 Sep 2000

Bibliographical note

Funding Information:
We thank Professor S. Kimel for helpful discussions and Ms J. Hanania for assistance in the preparation of the manuscript. This research was financially and technically supported by ESC Medical Systems Ltd.

Keywords

Melanoma
Melanosoma
Mice
Pulsed photothermic treatment
Vascular damage

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(00)00508-5

Cite this

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title = "Photothermic treatment of pigmented B16 melanoma using a broadband pulsed light delivery system",

abstract = "Pulsed photothermic treatment (PTT) of pigmented B16 mice melanoma tumors was carried out using a Photodyne({\textregistered}) incoherent light delivery system. Tumor heating with average temperature of 41-44°C was observed during broadband photoirradiation (600-800 nm) at light doses of 60-120 J/cm2 delivered using 0.6 J/cm2 pulses (2 ms) at 1 Hz repetition rate. Electron microscopy of tumor samples revealed pronounced structural changes in microvasculature and melanosomes. Pulsed PTT caused damage to endothelial cells and vascular walls, swelling of mitochondria and melanosomal disruption without nuclear alteration. Significant tumor response with necrosis formation followed by tumor regression was observed by a tumor growth study after PTT at 120 J/cm2. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Melanoma, Melanosoma, Mice, Pulsed photothermic treatment, Vascular damage",

author = "Genady Kostenich and Tatyana Babushkina and Zvi Malik and Arie Orenstein",

note = "Funding Information: We thank Professor S. Kimel for helpful discussions and Ms J. Hanania for assistance in the preparation of the manuscript. This research was financially and technically supported by ESC Medical Systems Ltd.",

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doi = "10.1016/S0304-3835(00)00508-5",

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AU - Kostenich, Genady

AU - Babushkina, Tatyana

AU - Malik, Zvi

AU - Orenstein, Arie

N1 - Funding Information: We thank Professor S. Kimel for helpful discussions and Ms J. Hanania for assistance in the preparation of the manuscript. This research was financially and technically supported by ESC Medical Systems Ltd.

PY - 2000/9/1

Y1 - 2000/9/1

N2 - Pulsed photothermic treatment (PTT) of pigmented B16 mice melanoma tumors was carried out using a Photodyne(®) incoherent light delivery system. Tumor heating with average temperature of 41-44°C was observed during broadband photoirradiation (600-800 nm) at light doses of 60-120 J/cm2 delivered using 0.6 J/cm2 pulses (2 ms) at 1 Hz repetition rate. Electron microscopy of tumor samples revealed pronounced structural changes in microvasculature and melanosomes. Pulsed PTT caused damage to endothelial cells and vascular walls, swelling of mitochondria and melanosomal disruption without nuclear alteration. Significant tumor response with necrosis formation followed by tumor regression was observed by a tumor growth study after PTT at 120 J/cm2. (C) 2000 Elsevier Science Ireland Ltd.

AB - Pulsed photothermic treatment (PTT) of pigmented B16 mice melanoma tumors was carried out using a Photodyne(®) incoherent light delivery system. Tumor heating with average temperature of 41-44°C was observed during broadband photoirradiation (600-800 nm) at light doses of 60-120 J/cm2 delivered using 0.6 J/cm2 pulses (2 ms) at 1 Hz repetition rate. Electron microscopy of tumor samples revealed pronounced structural changes in microvasculature and melanosomes. Pulsed PTT caused damage to endothelial cells and vascular walls, swelling of mitochondria and melanosomal disruption without nuclear alteration. Significant tumor response with necrosis formation followed by tumor regression was observed by a tumor growth study after PTT at 120 J/cm2. (C) 2000 Elsevier Science Ireland Ltd.

KW - Melanoma

KW - Melanosoma

KW - Mice

KW - Pulsed photothermic treatment

KW - Vascular damage

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JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Photothermic treatment of pigmented B16 melanoma using a broadband pulsed light delivery system

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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