@inproceedings{576cce30efe24e80a0491d3729db64e8,
title = "Photonic monitoring of chitosan nanostructured alginate microcapsules for drug release",
abstract = "By using a novel microfluidic set-up for drug screening applications, this study examines delivery of a novel risedronate based drug formulation for treatment of osteoporosis that was developed to overcome the usual shortcomings of risedronate, such as its low bioavailability and adverse gastric effects. Risedronate nanoparticles were prepared using muco-adhesive polymers such as chitosan as matrix for improving the intestinal cellular absorption of risedronate and also using a gastric-resistant polymer such as sodium alginate for reducing the gastric inflammation of risedronate. The in-vitro characteristics of the alginate encapsulated chitosan nanoparticles are investigated, including their stability, muco-adhesiveness, and Caco-2 cell permeability. Fluorescent markers are tagged with the polymers and their morphology within the microcapsules is imaged at various stages of drug release.",
keywords = "Chitosan, Drug delivery system, Microfluidic device, Osteoporosis, Risedronate sodium, Sodium alginate",
author = "Khajuria, {Deepak K.} and Konnur, {Manish C.} and Ramakrishna Vasireddi and {Roy Mahapatra}, D.",
year = "2015",
doi = "10.1117/12.2084966",
language = "אנגלית",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Kang, {Hyun Wook} and Ilgner, {Justus F.} and Skala, {Melissa C.} and Laura Marcu and Haishan Zeng and Dewhirst, {Mark W.} and Gregory, {Kenton W.} and Andreas Mandelis and Bernard Choi and Wong, {Brian Jet-Fei} and Claus-Peter Richter and Tearney, {Guillermo J.} and Alfred Nuttal and Nikiforos Kollias",
booktitle = "Photonic Therapeutics and Diagnostics XI",
address = "ארצות הברית",
note = "Photonic Therapeutics and Diagnostics XI ; Conference date: 07-02-2015 Through 08-02-2015",
}