Phospho-Tau Impairs Nuclear-Cytoplasmic Transport

Timir Tripathi, Jay Prakash, Yaron Shav-Tal

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Aggregation of hyperphosphorylated tau is the hallmark of several tauopathies, including Alzheimer's disease (AD). Although the mechanism underlying tau-associated neuronal damage remains unclear, it is believed that tau hyperphosphorylation is one of the key features in disease progression. A recent study demonstrates that hyperphosphorylated tau (P-tau) interacts with components of the nuclear pore complex (NPC) to impair nuclear-cytoplasmic transport and contribute to tau-induced neurotoxicity. The NPC thus represents a point of convergence between pathological tau and neuronal dysfunction in AD.

Original languageEnglish
Pages (from-to)36-38
Number of pages3
JournalACS Chemical Neuroscience
Volume10
Issue number1
DOIs
StatePublished - 16 Jan 2019

Bibliographical note

Publisher Copyright:
© 2018 American Chemical Society.

Keywords

  • Alzheimer's disease
  • NPC structure
  • Nuclear pore complex
  • aggregation
  • hyperphosphorylated tau
  • nuclear-cytoplasmic transport
  • nucleoporins
  • tauopathies

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