Pharmacophore and docking-based hierarchical virtual screening for the designing of aldose reductase inhibitors: Synthesis and biological evaluation

Keyphrases

• Synthetic Evaluation 100%
• Biological Evaluation 100%
• Pharmacophore 100%
• Hierarchical Virtual Screening 100%
• ALR2 100%
• Aldose Reductase Inhibitor 100%
• Inhibitor Synthesis 100%
• Inhibitory Activity 66%
• Diabetes Complications 66%
• Analysis Parameters 33%
• Best Model 33%
• Schrdinger 33%
• IC50 33%
• Pharmacokinetic Parameters 33%
• Pharmacophore Model 33%
• Pharmacophore Modeling 33%
• Active Molecules 33%
• Flavonoids 33%
• Statistical Parameters 33%
• Antioxidant Potential 33%
• Orally Active 33%
• Parameter Calculation 33%
• 3D-QSAR 33%
• Q Test 33%
• QSAR Analysis 33%
• 3D-QSAR Model 33%
• Docking Analysis 33%
• PHASE Program 33%
• Aldose Reductase 33%
• ALR2 Inhibitor 33%
• Free Radical Scavenging Potential 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Virtual Screening 100%
• Quantitative Structure-Activity Relationship 100%
• Diabetic Complication 100%
• Aldose Reductase Inhibitor 100%
• Pharmacokinetic Parameter 50%
• Flavonoid 50%
• Free Radical 50%
• Aldehyde Reductase 50%
• Antioxidant 50%
• IC50 50%

Biochemistry, Genetics and Molecular Biology

• Pharmacophore 100%
• Aldose Reductase Inhibitor 100%
• Three Dimensional Quantitative Structure Activity Relationship 66%
• Aldose Reductase 33%
• Enzyme 33%
• IC50 33%
• Flavonoid 33%
• Quantitative Structure Activity Relation 33%
• Pharmacokinetics 33%