TY - JOUR
T1 - Pharmacological Insights
T2 - Mitochondrial ROS Generation by FNC (Azvudine) in Dalton’s Lymphoma Cells Revealed by Super Resolution Imaging
AU - Kumar, Naveen
AU - Delu, Vikram
AU - Ulasov, Ilya
AU - Kumar, Sanjay
AU - Singh, Rishi Kant
AU - Kumar, Sandeep
AU - Shukla, Alok
AU - Patel, Anand Kumar
AU - Yadav, Lokesh
AU - Tiwari, Ruchi
AU - Rachana, Kumari
AU - Mohanta, Shivashish Priyadarshi
AU - Singh, Varsha
AU - Yadav, Anuradha
AU - Kaushalendra, Kaushalendra
AU - Acharya, Arbind
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2024/6
Y1 - 2024/6
N2 - Nucleoside analogs are a common form of chemotherapy that disrupts DNA replication and repair, leading to cell cycle arrest and apoptosis. Reactive oxygen species (ROS) production is a significant mechanism through which these drugs exert their anticancer effects. This study investigated a new nucleoside analog called FNC or Azvudine, and its impact on ROS production and cell viability in Dalton’s lymphoma (DL) cells. The study found that FNC treatment resulted in a time- and dose-dependent increase in ROS levels in DL cells. After 15 and 30 min of treatment with 2 and 1 mg/ml of FNC, mitochondrial ROS production was observed in DL cells. Furthermore, prolonged exposure to FNC caused structural alterations and DNA damage in DL cells. The results suggest that FNC’s ability to impair DL cell viability may be due to its induction of ROS production and indicate a need for further investigation.
AB - Nucleoside analogs are a common form of chemotherapy that disrupts DNA replication and repair, leading to cell cycle arrest and apoptosis. Reactive oxygen species (ROS) production is a significant mechanism through which these drugs exert their anticancer effects. This study investigated a new nucleoside analog called FNC or Azvudine, and its impact on ROS production and cell viability in Dalton’s lymphoma (DL) cells. The study found that FNC treatment resulted in a time- and dose-dependent increase in ROS levels in DL cells. After 15 and 30 min of treatment with 2 and 1 mg/ml of FNC, mitochondrial ROS production was observed in DL cells. Furthermore, prolonged exposure to FNC caused structural alterations and DNA damage in DL cells. The results suggest that FNC’s ability to impair DL cell viability may be due to its induction of ROS production and indicate a need for further investigation.
KW - Azvudine
KW - Cell survival
KW - DNA damage
KW - DNA replication
KW - Nucleoside analogs
UR - http://www.scopus.com/inward/record.url?scp=85187882738&partnerID=8YFLogxK
U2 - 10.1007/s12013-024-01238-4
DO - 10.1007/s12013-024-01238-4
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C2 - 38483755
AN - SCOPUS:85187882738
SN - 1085-9195
VL - 82
SP - 873
EP - 883
JO - Cell Biochemistry and Biophysics
JF - Cell Biochemistry and Biophysics
IS - 2
ER -