pH-stimulated DNA hydrogels exhibiting shape-memory properties

Weiwei Guo, Chun Hua Lu, Ron Orbach, Fuan Wang, Xiu Juan Qi, Alessandro Cecconello, Dror Seliktar, Itamar Willner

Research output: Contribution to journalArticlepeer-review

205 Scopus citations


(Figure Presented) Nucleic acid-functionalized polyacrylamide chains that are cooperatively cross-linked by i-motif and nucleic acid duplex units yield, at pH 5.0, DNA hydrogels exhibiting shape-memory properties. Separation of the i-motif units at pH 8.0 dissolves the hydrogel into a quasi-liquid phase. The residual duplex units provide, however, a memory code in the quasi-liquid allowing the regeneration of the hydrogel shape at pH 5.0.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalAdvanced Materials
Issue number1
StatePublished - 6 Nov 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 Wiley-VCH Verlag GmbH & Co. KGaA.


  • Acrylamide
  • Gel
  • I-motif
  • Nucleic acid
  • Switch


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