pH-stimulated DNA hydrogels exhibiting shape-memory properties

Weiwei Guo; Chun Hua Lu; Ron Orbach; Fuan Wang; Xiu Juan Qi; Alessandro Cecconello; Dror Seliktar; Itamar Willner

doi:10.1002/adma.201403702

pH-stimulated DNA hydrogels exhibiting shape-memory properties

Weiwei Guo, Chun Hua Lu, Ron Orbach, Fuan Wang, Xiu Juan Qi, Alessandro Cecconello, Dror Seliktar, Itamar Willner

Research output: Contribution to journal › Article › peer-review

247 Scopus citations

Abstract

(Figure Presented) Nucleic acid-functionalized polyacrylamide chains that are cooperatively cross-linked by i-motif and nucleic acid duplex units yield, at pH 5.0, DNA hydrogels exhibiting shape-memory properties. Separation of the i-motif units at pH 8.0 dissolves the hydrogel into a quasi-liquid phase. The residual duplex units provide, however, a memory code in the quasi-liquid allowing the regeneration of the hydrogel shape at pH 5.0.

Original language	English
Pages (from-to)	73-78
Number of pages	6
Journal	Advanced Materials
Volume	27
Issue number	1
DOIs	https://doi.org/10.1002/adma.201403702
State	Published - 7 Jan 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 Wiley-VCH Verlag GmbH & Co. KGaA.

Keywords

Acrylamide
Gel
I-motif
Nucleic acid
Switch

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10.1002/adma.201403702

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abstract = "(Figure Presented) Nucleic acid-functionalized polyacrylamide chains that are cooperatively cross-linked by i-motif and nucleic acid duplex units yield, at pH 5.0, DNA hydrogels exhibiting shape-memory properties. Separation of the i-motif units at pH 8.0 dissolves the hydrogel into a quasi-liquid phase. The residual duplex units provide, however, a memory code in the quasi-liquid allowing the regeneration of the hydrogel shape at pH 5.0.",

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AU - Guo, Weiwei

AU - Lu, Chun Hua

AU - Orbach, Ron

AU - Wang, Fuan

AU - Qi, Xiu Juan

AU - Cecconello, Alessandro

AU - Seliktar, Dror

AU - Willner, Itamar

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N2 - (Figure Presented) Nucleic acid-functionalized polyacrylamide chains that are cooperatively cross-linked by i-motif and nucleic acid duplex units yield, at pH 5.0, DNA hydrogels exhibiting shape-memory properties. Separation of the i-motif units at pH 8.0 dissolves the hydrogel into a quasi-liquid phase. The residual duplex units provide, however, a memory code in the quasi-liquid allowing the regeneration of the hydrogel shape at pH 5.0.

AB - (Figure Presented) Nucleic acid-functionalized polyacrylamide chains that are cooperatively cross-linked by i-motif and nucleic acid duplex units yield, at pH 5.0, DNA hydrogels exhibiting shape-memory properties. Separation of the i-motif units at pH 8.0 dissolves the hydrogel into a quasi-liquid phase. The residual duplex units provide, however, a memory code in the quasi-liquid allowing the regeneration of the hydrogel shape at pH 5.0.

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KW - Gel

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KW - Nucleic acid

KW - Switch

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pH-stimulated DNA hydrogels exhibiting shape-memory properties

Abstract

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Keywords

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