Peripartum maternal transmission of extended-spectrum β-lactamase organism to newborn infants

Avi Peretz; Alina Skuratovsky; Efrat Khabra; Amos Adler; Nina Pastukh; Shay Barak; Yuri Perlitz; Moshe Ben-Ami; Amir Kushnir

doi:10.1016/j.diagmicrobio.2016.11.004

Peripartum maternal transmission of extended-spectrum β-lactamase organism to newborn infants

Avi Peretz, Alina Skuratovsky, Efrat Khabra, Amos Adler, Nina Pastukh, Shay Barak, Yuri Perlitz, Moshe Ben-Ami, Amir Kushnir

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The aim of this study was to determine whether the route of extended-spectrum β-lactamase (ESBL) transmission to hospitalized newborns was from their mothers during delivery. Neonatal intensive care unit (NICU) hospitalized newborns were sampled for ESBL presence by stool cultures on the first and fourth days of life. Mothers of ESBL-positive newborns were sampled for possible correlation detection. Bacteria isolates were molecularly identified and susceptibility tests for antibiotic agents were performed. Of the 225 newborns, 14 (6.2%) were ESBL positive, 10 (4.4%) were Escherichia coli positive, and 4 (1.7%) were Klebsiella pneumoniae positive. Among the 14 mothers of positive newborns, 13 (92.8%) were found ESBL positive and one mother of a newborn with E. coli carriage was found ESBL negative. Genes encoding for ESBL resistance were identified. Antibiotic sensitivity and resistance were tested. This study demonstrated that ESBL bacteria carrier neonates hospitalized in NICU may be a result of transmission from mother to baby during delivery.

Original language	English
Pages (from-to)	168-171
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	87
Issue number	2
DOIs	https://doi.org/10.1016/j.diagmicrobio.2016.11.004
State	Published - 1 Feb 2017

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

E. coli
ESBL
K. pneumoniae
Neonatal intensive care units
Newborn

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diagmicrobio.2016.11.004

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abstract = "The aim of this study was to determine whether the route of extended-spectrum β-lactamase (ESBL) transmission to hospitalized newborns was from their mothers during delivery. Neonatal intensive care unit (NICU) hospitalized newborns were sampled for ESBL presence by stool cultures on the first and fourth days of life. Mothers of ESBL-positive newborns were sampled for possible correlation detection. Bacteria isolates were molecularly identified and susceptibility tests for antibiotic agents were performed. Of the 225 newborns, 14 (6.2%) were ESBL positive, 10 (4.4%) were Escherichia coli positive, and 4 (1.7%) were Klebsiella pneumoniae positive. Among the 14 mothers of positive newborns, 13 (92.8%) were found ESBL positive and one mother of a newborn with E. coli carriage was found ESBL negative. Genes encoding for ESBL resistance were identified. Antibiotic sensitivity and resistance were tested. This study demonstrated that ESBL bacteria carrier neonates hospitalized in NICU may be a result of transmission from mother to baby during delivery.",

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AU - Perlitz, Yuri

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Peripartum maternal transmission of extended-spectrum β-lactamase organism to newborn infants

Abstract

Bibliographical note

Keywords

UN SDGs

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