Peptides and thermoregulation

Shlomo Yehuda, Abba J. Kastin

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Several peptides are now known to affect thermoregulation. These include beta-endorphin, bombesin, MIF-I, alpha-MSH, neurotensin, TRH, and DSIP. Some of these have been found to interact with the thermal effects of d-amphetamine, a drug with well established actions on thermoregulation. The effects of morphine on body temperature provide some notable comparisons with beta-endorphin, as do the similarities between the effects of naloxone and MIF-I. In general, it seems that two of the major variables which interact and modify the thermal effects of peptides are ambient temperature and route of administration.

Original languageEnglish
Pages (from-to)459-471
Number of pages13
JournalNeuroscience and Biobehavioral Reviews
Volume4
Issue number4
DOIs
StatePublished - 1980
Externally publishedYes

Bibliographical note

Funding Information:
Supported in part by the Medical Research Service of the Veterans Administration, NIH (NS 07664), and The American Parkinson Disease Foundation.

Funding

Supported in part by the Medical Research Service of the Veterans Administration, NIH (NS 07664), and The American Parkinson Disease Foundation.

FundersFunder number
Medical Research Service of the Veterans Administration
National Institutes of HealthNS 07664
American Parkinson's Disease Foundation

    Keywords

    • Alpha-MSH
    • Ambient temperature
    • Beta-endorphin
    • Bombesin
    • DSIP
    • Drug interaction
    • Hyperthermia
    • Hypothermia
    • MIF-I
    • Morphine
    • Naloxone
    • Neurotensin
    • Peptides
    • TRH
    • Thermoregulation
    • d-Amphetamine

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