Peptides and peptidomimetics as regulators of protein–protein interactions

Anna D. Cunningham, Nir Qvit, Daria Mochly-Rosen

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations


Protein–protein interactions are essential for almost all intracellular and extracellular biological processes. Regulation of protein–protein interactions is one strategy to regulate cell fate in a highly selective manner. Specifically, peptides are ideal candidates for inhibition of protein–protein interactions because they can mimic a protein surface to effectively compete for binding. Additionally, peptides are synthetically accessible and can be stabilized by chemical modifications. In this review, we survey screening and rational design methods for identifying peptides to inhibit protein–protein interactions, as well as methods for stabilizing peptides to effectively mimic protein surfaces. In addition, we discuss recent applications of peptides to regulate protein–protein interactions for both basic research and therapeutic purposes.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalCurrent Opinion in Structural Biology
StatePublished - 1 Jun 2017
Externally publishedYes

Bibliographical note

Funding Information:
The work was supported by National Institutes of Health grant HL52141 to D.M.-R.

Publisher Copyright:
© 2016 Elsevier Ltd


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