TY - JOUR
T1 - Penicillin V twice daily vs. Four times daily in the treatment of streptococcal pharyngitis
AU - Raz, R.
AU - Elchanan, G.
AU - Colodner, R.
AU - Reiss, S.
AU - Schvartzman, P.
AU - Tabenkin, H.
AU - Leshem, Y.
PY - 1995/1
Y1 - 1995/1
N2 - Treatment failure of streptococcal pharyngitis with oral penicillin might be due to patient noncompliance. We performed a randomized controlled study of 104 patients with group A ß-hemolytic streptococcal pharyngitis; 51 patients received penicillin V 1 g twice daily and 53 patients, 500 mg four times a day for 10 days. At day 9-10 of treatment, the number of patients free of symptoms was significantly greater in the twice-daily than in the four-times-daily group (92% vs. 77%); similarly, the number of patients with sterile throat cultures was significantly greater in the twice-daily group (90% vs. 73%). Differences in clinical and bactériologie responses were still significant 28 days posttherapy. Compliance was 90% in the twice-daily group vs. 58%. Penicillin V given twice daily is more effective than a four-times-daily regimen in the treatment of streptococcal pharyngitis, probably because patient compliance is improved.
AB - Treatment failure of streptococcal pharyngitis with oral penicillin might be due to patient noncompliance. We performed a randomized controlled study of 104 patients with group A ß-hemolytic streptococcal pharyngitis; 51 patients received penicillin V 1 g twice daily and 53 patients, 500 mg four times a day for 10 days. At day 9-10 of treatment, the number of patients free of symptoms was significantly greater in the twice-daily than in the four-times-daily group (92% vs. 77%); similarly, the number of patients with sterile throat cultures was significantly greater in the twice-daily group (90% vs. 73%). Differences in clinical and bactériologie responses were still significant 28 days posttherapy. Compliance was 90% in the twice-daily group vs. 58%. Penicillin V given twice daily is more effective than a four-times-daily regimen in the treatment of streptococcal pharyngitis, probably because patient compliance is improved.
UR - http://www.scopus.com/inward/record.url?scp=0028878558&partnerID=8YFLogxK
U2 - 10.1097/00019048-199501000-00015
DO - 10.1097/00019048-199501000-00015
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AN - SCOPUS:0028878558
SN - 1056-9103
VL - 4
SP - 50
EP - 54
JO - Infectious Diseases in Clinical Practice
JF - Infectious Diseases in Clinical Practice
IS - 1
ER -