PEG-Biscyanoacrylate Crosslinker for Octyl Cyanoacrylate Bioadhesive

Arijit Basu; Ilana Veprinsky-Zuzulia; Mira Levinman; Yoav Barkan; Jacob Golenser; Abraham J. Domb

doi:10.1002/marc.201500567

PEG-Biscyanoacrylate Crosslinker for Octyl Cyanoacrylate Bioadhesive

Arijit Basu, Ilana Veprinsky-Zuzulia, Mira Levinman, Yoav Barkan, Jacob Golenser, Abraham J. Domb

Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

PEG400 (polyethylene glycol, M_W 400) biscyanoacrylate is synthesized and copolymerized with 2-octyl cyanoacrylate for potential use as bioadhesive. PEG400 biscyanoacrylate is synthesized from the esterification of anthracenyl cyanoacrylic acid where the anthracene unit serves as vinyl-protecting group. Copolymerization increases the plasticity, mechanical strength, and resilience of the resulted polymer as determined by dynamic mechanical analysis. Peeling test confirms its superior bioadhesive properties. Surface morphology is characterized by SEM imaging. The formulations are cytocompatible and safe. This cyanoacrylate composition may provide improved bioadhesive cyanoacrylates.

Original language	English
Pages (from-to)	251-256
Number of pages	6
Journal	Macromolecular Rapid Communications
Volume	37
Issue number	3
DOIs	https://doi.org/10.1002/marc.201500567
State	Published - 1 Feb 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

2-octyl cyanoacrylate
PEG biscyanoacrylate
bioadhesives
plasticity
viscoelasticity

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10.1002/marc.201500567

Cite this

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title = "PEG-Biscyanoacrylate Crosslinker for Octyl Cyanoacrylate Bioadhesive",

abstract = "PEG400 (polyethylene glycol, MW 400) biscyanoacrylate is synthesized and copolymerized with 2-octyl cyanoacrylate for potential use as bioadhesive. PEG400 biscyanoacrylate is synthesized from the esterification of anthracenyl cyanoacrylic acid where the anthracene unit serves as vinyl-protecting group. Copolymerization increases the plasticity, mechanical strength, and resilience of the resulted polymer as determined by dynamic mechanical analysis. Peeling test confirms its superior bioadhesive properties. Surface morphology is characterized by SEM imaging. The formulations are cytocompatible and safe. This cyanoacrylate composition may provide improved bioadhesive cyanoacrylates.",

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author = "Arijit Basu and Ilana Veprinsky-Zuzulia and Mira Levinman and Yoav Barkan and Jacob Golenser and Domb, \{Abraham J.\}",

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AU - Basu, Arijit

AU - Veprinsky-Zuzulia, Ilana

AU - Levinman, Mira

AU - Barkan, Yoav

AU - Golenser, Jacob

AU - Domb, Abraham J.

PY - 2016/2/1

Y1 - 2016/2/1

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KW - 2-octyl cyanoacrylate

KW - PEG biscyanoacrylate

KW - bioadhesives

KW - plasticity

KW - viscoelasticity

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PEG-Biscyanoacrylate Crosslinker for Octyl Cyanoacrylate Bioadhesive

Abstract

Bibliographical note

Keywords

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