PEG-Biscyanoacrylate Crosslinker for Octyl Cyanoacrylate Bioadhesive

Arijit Basu, Ilana Veprinsky-Zuzulia, Mira Levinman, Yoav Barkan, Jacob Golenser, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


PEG400 (polyethylene glycol, MW 400) biscyanoacrylate is synthesized and copolymerized with 2-octyl cyanoacrylate for potential use as bioadhesive. PEG400 biscyanoacrylate is synthesized from the esterification of anthracenyl cyanoacrylic acid where the anthracene unit serves as vinyl-protecting group. Copolymerization increases the plasticity, mechanical strength, and resilience of the resulted polymer as determined by dynamic mechanical analysis. Peeling test confirms its superior bioadhesive properties. Surface morphology is characterized by SEM imaging. The formulations are cytocompatible and safe. This cyanoacrylate composition may provide improved bioadhesive cyanoacrylates.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalMacromolecular Rapid Communications
Issue number3
StatePublished - 1 Feb 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


  • 2-octyl cyanoacrylate
  • PEG biscyanoacrylate
  • bioadhesives
  • plasticity
  • viscoelasticity


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