Pathophysiology of sars-cov-2 infection in the upper respiratory tract and its relation to breath volatile organic compounds

Moria Lichtenstein, Sondra Turjerman, Jayant M. Pinto, Orna Barash, Omry Koren

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Among the many products of metabolic processes are volatile organic compounds (VOCs). In the airways, these volatile metabolites are emitted through breathing and thus are easily sampled for analysis. Recent work has connected the functions and structure of the human microbiome with health and disease. Alteration in microbial function in this context can result in differences in metabolite composition, including that of VOCs, presenting the possibility of a new noninvasive method for clinical diagnosis. Screening methods that assess VOCs arising from changes in the airway microbiome could be highly useful in diagnosing viral upper respiratory tract infections (URTIs), e.g., COVID-19, which are highly contagious and have an enormous public health impact worldwide. A rapid noninvasive screening test for URTIs would pose major advantages in containing the disease. As early evidence shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection alters the human microbiome (both in the gut and the respiratory tract), we propose that detection of a VOC signature of an altered nasal microbiome could be fruitful as a rapid noninvasive measure of URTI in general and of SARS-CoV-2 in particular.

Original languageEnglish
Article numbere00104-21
Issue number4
StatePublished - 31 Aug 2021

Bibliographical note

Publisher Copyright:
© 2021 Lichtenstein et al.


FundersFunder number
Horizon 2020 Framework Programme961108


    • COVID-19
    • Microbiome
    • Severe acute respiratory syndrome coronavirus 2
    • Upper respiratory tract infections
    • Volatile organic compounds


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