Pathophysiological role of cytokines in congestive heart failure

A. Blum, H. Miller

Research output: Contribution to journalReview articlepeer-review

121 Scopus citations


Heart failure is a complex neurohumoral and inflammatory syndrome. Recent studies have shown that proinflammatory cytokines (interleukin-1, interleukin-2, interleukin-6, interleukin-10, and tumor necrosis factor) are involved in cardiac depression and in the complex syndrome of heart failure. Understanding the involvement of these cytokines may enable us to reverse cardiac depression and heart failure by the use of monoclonal antibodies directed against specific cytokines to block the downhill progression of heart failure.

Original languageEnglish
Pages (from-to)15-27
Number of pages13
JournalAnnual Review of Medicine
StatePublished - 2001
Externally publishedYes


  • Atrial natriuretic factor
  • Dilated cardiomyopathy
  • Interleukin-1β
  • Interleukin-2
  • Interleukin-6
  • Major histocompatibility complex
  • Monoclonal antibodies
  • Tumor necrosis factor α


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