TY - JOUR
T1 - Pasty polymers in cancer drug therapy
AU - Pawar, Rajendra P.
AU - Kharat, Kiran R.
AU - Domb, Abraham J.
PY - 2010/8
Y1 - 2010/8
N2 - Injectable polymeric systems suitable for the localized delivery of anticancer agents are reviewed. These polymeric systems include: drug-loaded low melting temperature polymers that are injected at the melting temperature of the polymer, usually below 50-°C, that solidify at body temperature to form an in situ device; polymer solutions in buffer or in N-methyl pyrrolidone, ethanol, or acetate esters which, upon injection in tissue,are absorbed into the tissue and cause precipitation of the polymer at the injection site; in situ crosslinking of polymer solutions to form a polymeric implant; and thermoresponsive polymer solutions that are soluble at room temperature and solidify at body temperature. However, these systems are hydrophilic and suffer from burst release of drug within a few hours post injection. Hydrophobic injectable, pasty, fat-based polymers that gel when injected in tissue have been used for the extended release of paclitaxel, cisplatin, and other agents. This polymer releases the drug in a controlled manner with no burst release. These systems have a potential use as drug carriers for regional or systemic drug delivery.
AB - Injectable polymeric systems suitable for the localized delivery of anticancer agents are reviewed. These polymeric systems include: drug-loaded low melting temperature polymers that are injected at the melting temperature of the polymer, usually below 50-°C, that solidify at body temperature to form an in situ device; polymer solutions in buffer or in N-methyl pyrrolidone, ethanol, or acetate esters which, upon injection in tissue,are absorbed into the tissue and cause precipitation of the polymer at the injection site; in situ crosslinking of polymer solutions to form a polymeric implant; and thermoresponsive polymer solutions that are soluble at room temperature and solidify at body temperature. However, these systems are hydrophilic and suffer from burst release of drug within a few hours post injection. Hydrophobic injectable, pasty, fat-based polymers that gel when injected in tissue have been used for the extended release of paclitaxel, cisplatin, and other agents. This polymer releases the drug in a controlled manner with no burst release. These systems have a potential use as drug carriers for regional or systemic drug delivery.
KW - Cancer therapy
KW - Controlled release
KW - Drug delivery
KW - In-situ implants
KW - Injectable polymers
UR - http://www.scopus.com/inward/record.url?scp=78649279842&partnerID=8YFLogxK
U2 - 10.1002/ijch.201000027
DO - 10.1002/ijch.201000027
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AN - SCOPUS:78649279842
SN - 0021-2148
VL - 50
SP - 233
EP - 238
JO - Israel Journal of Chemistry
JF - Israel Journal of Chemistry
IS - 2
ER -
