Parents' attitudes toward methylphenidate using n-of-1 trial: A pilot study

Dorit Taragin, Suzana Berman, Nathanel Zelnik, Avi Karni, Emanuel Tirosh

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


To compare parents' attitudes toward methylphenidate treatment in children with attention deficit hyperactivity disorder employing two approaches: (1) a 2-week double-blind placebo-drug trial (n-of-1 trial), (2) a traditional prescription approach. The study group (N-50) and a comparison group (N-45) were recruited. The Abbreviated Acceptability Rating Profile was administered prior to and following the pediatricians' consultation, and in 2, 4, and 8 weeks after prescription. Complete data set was available for 21 children in each group. While initial attitudes were similar, a significantly more favorable attitude following the performance of an n-of-1 trial and throughout the follow-up in the study group only was noted. Adherence was significantly correlated with attitude score in the study group only. An individual n-of-1 trial with methylphenidate appears to positively affect parents' attitudes toward drug treatment and may also help adherence with this treatment.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalADHD Attention Deficit and Hyperactivity Disorders
Issue number2
StatePublished - Jun 2013
Externally publishedYes


  • Attention deficit hyperactivity disorder (ADHD)
  • Methylphenidate
  • n-of-1 trial
  • Parents' attitudes


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