PAR4 activation involves extracellular loop 3 and transmembrane residue Thr153

Keyphrases

• Transmembrane 100%
• Extracellular Loop 100%
• Protease-activated Receptor 4 (PAR4) 100%
• Ligand Binding Site 40%
• Hydrogen-deuterium Exchange 40%
• Tethered Ligands 40%
• Venous Thromboembolism 30%
• Computational Modeling 20%
• Odds Ratio 10%
• Molecular Mechanism 10%
• Polymorphism 10%
• Meta-analysis 10%
• Confidence Interval 10%
• Platelets 10%
• Molecular Signaling 10%
• Venous Thrombosis 10%
• Thrombus 10%
• Relative Risk 10%
• Proline 10%
• Genome-wide Association Study 10%
• Sequence Variants 10%
• Molecular Modeling 10%
• Thrombin 10%
• Proteolysis 10%
• N-terminus 10%
• Gatekeepers 10%
• International Networks 10%
• Multi-ancestry 10%
• Ligand-mediated 10%

Biochemistry, Genetics and Molecular Biology

• Protease-Activated Receptor 100%
• Ligand Binding 40%
• Binding Site 40%
• Hydrogen-Deuterium Exchange 40%
• Allele 20%
• N-Terminus 10%
• Proline 10%
• Molecular Modeling 10%
• Protein Catabolism 10%
• Rigidity 10%
• Molecular Model 10%
• Platelet 10%
• Thrombin 10%
• Genome-Wide Association Study 10%
• Phlebothrombosis 10%