TY - GEN
T1 - Panel construction for mapping in admixed populations via expected mutual information
AU - Bercovici, Sivan
AU - Geiger, Dan
AU - Shlush, Liran
AU - Skorecki, Karl
AU - Templeton, Alan
PY - 2008
Y1 - 2008
N2 - Mapping by Admixture Linkage Disequilibrium (MALD) is an economical and powerful approach for the identification of genomic regions harboring disease susceptibility genes in recently admixed populations. We develop an information-theory based measure, called EMI (expected mutual information), that computes the impact of a set of markers on the ability to infer ancestry at each chromosomal location. We then present a simple and effective algorithm for the selection of panels that strives to maximize the EMI score. Finally, we demonstrate via well established simulation tools that our panels provide considerably more power and accuracy for inferring disease gene loci via the MALD method in comparison to previous methods.
AB - Mapping by Admixture Linkage Disequilibrium (MALD) is an economical and powerful approach for the identification of genomic regions harboring disease susceptibility genes in recently admixed populations. We develop an information-theory based measure, called EMI (expected mutual information), that computes the impact of a set of markers on the ability to infer ancestry at each chromosomal location. We then present a simple and effective algorithm for the selection of panels that strives to maximize the EMI score. Finally, we demonstrate via well established simulation tools that our panels provide considerably more power and accuracy for inferring disease gene loci via the MALD method in comparison to previous methods.
UR - http://www.scopus.com/inward/record.url?scp=47249140478&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-78839-3_39
DO - 10.1007/978-3-540-78839-3_39
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AN - SCOPUS:47249140478
SN - 3540788387
SN - 9783540788386
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 435
EP - 449
BT - Research in Computational Molecular Biology - 12th Annual International Conference, RECOMB 2008, Proceedings
T2 - "12th Annual InternationalConference on REsearch in COmputational Molecular Biology, RECOMB 2008"
Y2 - 30 March 2008 through 2 April 2008
ER -