TY - JOUR
T1 - Pancreatic cancer in Israel
T2 - The epidemiology, possibilities of prevention, early detection and screening
AU - Rozen, Paul
AU - Liphshitz, Irena
AU - Rosner, Guy
AU - Barchana, Micha
AU - Lachter, Jesse
AU - Pel, Sara
AU - Shohat, Tami
AU - Santo, Erwin
AU - Biderman, Y.
AU - Meltzer, E.
AU - Fireman, Z.
AU - Leichtman, G.
AU - Scapa, E.
PY - 2009/12
Y1 - 2009/12
N2 - Pancreatic cancer is not a common malignancy in Israel, but it is the third most common cause of cancer mortality, attributable to a lack of screening tests, inaccessibility of the pancreas, and late cancer stage at diagnosis. We reviewed the epidemiology, known risk factors and screening methods available in Israel and describe the Israeli national consortium that was established to identify persons at risk and decide on screening methods to detect and treat their early-stage pancreatic cancer. In collaboration with the Israel National Cancer Registry, we evaluated the incidence and trends of the disease in the Jewish and non-Jewish populations. The consortium reviewed known lifestyle risk habits, genetic causes, and screening methodologies used and available in Israel. Overall, there are about 600 new patients per year, with the highest incidence occurring in Jewish men of European birth (age-standardized rate 8.11/105 for 2003-06). The 5 year survival is about 5%. The consortium concluded that screening will be based on endoscopic ultrasonography. Pancreatic cancer patients and families at risk will be enrolled, demographic and lifestyle data collected and a cancer pedigree generated. Risk factors will be identified and genetic tests performed as required. This concerted national program to identify persons at risk, recommend which environmental risk factors to avoid and treat, and perform endoscopic ultrasound and genetic screening where appropriate, might reduce the incidence of invasive pancreatic cancer and/or improve its prognosis.
AB - Pancreatic cancer is not a common malignancy in Israel, but it is the third most common cause of cancer mortality, attributable to a lack of screening tests, inaccessibility of the pancreas, and late cancer stage at diagnosis. We reviewed the epidemiology, known risk factors and screening methods available in Israel and describe the Israeli national consortium that was established to identify persons at risk and decide on screening methods to detect and treat their early-stage pancreatic cancer. In collaboration with the Israel National Cancer Registry, we evaluated the incidence and trends of the disease in the Jewish and non-Jewish populations. The consortium reviewed known lifestyle risk habits, genetic causes, and screening methodologies used and available in Israel. Overall, there are about 600 new patients per year, with the highest incidence occurring in Jewish men of European birth (age-standardized rate 8.11/105 for 2003-06). The 5 year survival is about 5%. The consortium concluded that screening will be based on endoscopic ultrasonography. Pancreatic cancer patients and families at risk will be enrolled, demographic and lifestyle data collected and a cancer pedigree generated. Risk factors will be identified and genetic tests performed as required. This concerted national program to identify persons at risk, recommend which environmental risk factors to avoid and treat, and perform endoscopic ultrasound and genetic screening where appropriate, might reduce the incidence of invasive pancreatic cancer and/or improve its prognosis.
KW - Cancer
KW - Consortium
KW - Endoscopic ultrasonography
KW - Genetics
KW - Israel
KW - Pancreas
KW - Prevention
KW - Screening
UR - http://www.scopus.com/inward/record.url?scp=75449103538&partnerID=8YFLogxK
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C2 - 20166335
AN - SCOPUS:75449103538
SN - 1565-1088
VL - 11
SP - 610
EP - 613
JO - Israel Medical Association Journal
JF - Israel Medical Association Journal
IS - 12
ER -