Palladium-Assisted Removal of a Solubilizing Tag from a Cys Side Chain to Facilitate Peptide and Protein Synthesis

Suman Kumar Maity, Guy Mann, Muhammad Jbara, Shay Laps, Guy Kamnesky, Ashraf Brik

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Reversible attachment of solubilizing tags to hydrophobic peptides to facilitate their purification and ligation is an essential yet challenging task in chemical protein synthesis. The efficient palladium-assisted removal of the solubilizing tag linked to the Cys side chain is reported. The strategy was applied for the efficient preparation of histone protein H4 from two fragments via one-pot operation of ligation, removal of the solubilizing tag, and desulfurization.

Original languageEnglish
Pages (from-to)3026-3029
Number of pages4
JournalOrganic Letters
Volume18
Issue number12
DOIs
StatePublished - 17 Jun 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 American Chemical Society.

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