Pairing computation with experimentation: A powerful coupling for understanding T cell signalling

Arup K. Chakraborty, Jayajit Das

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


T cells are activated when extracellular stimuli, such as a ligand binding to the T cell receptor, are converted into functional outputs by the T cell signalling network. T cell receptor signalling is a highly complex, stochastic and dynamic process involving many interacting proteins. This complexity often confounds intuition, making it difficult to develop mechanistic principles that underly experimental observations. In this Review, we describe how computational approaches can partner successfully with biological experimentation to help address this challenge, and we illustrate this paradigm by summarizing recent work that shows new aspects of the T cell signalling network.

Original languageEnglish
Pages (from-to)59-71
Number of pages13
JournalNature Reviews Immunology
Issue number1
StatePublished - Jan 2010
Externally publishedYes

Bibliographical note

Funding Information:
We thank J. Roose, H. Eisen and A. Weiss for comments on the manuscript. A.K.C. is grateful to M. Davis, A. Shaw and A. Weiss for continuing collaborations and lessons in T cell signalling. Financial support was provided by the US National Institutes of Health (NIH) Director’s Pioneer Award and 1PO1/ AI071195/01.


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