PA-II, the L-fucose and D-mannose binding lectin of Pseudomonas aeruginosa stimulates human peripheral lymphocytes and murine splenocytes

Dody Avichezer, Nechama Gilboa-Garber

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Pseudomonas aeruginosa lectin PA-II agglutinates human peripheral lymphocytes and stimulates mitogenesis (predominantly in T cells), like the plant lectins PHA and Con A. Murine splenocytes are also agglutinated and stimulated by PA-II as by Con A. Sialidase treatment of the human and murine cells enhances their agglutination and augments the stimulation of human lymphocytes at low PA-II concentrations. The PA-II agglutinating and mitogenic effects are specifically inhibited by L-fucose. The bacterial source and the specificity of PA-II for L-fucose are both rare features among the hitherto described mitogenic lectins. However, since this lectin also binds mannose, a mannose-bearing receptor might be involved in its mitogenicity.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalFEBS Letters
Volume216
Issue number1
DOIs
StatePublished - 25 May 1987

Bibliographical note

Funding Information:
This studyr epresentas part of a thesiss ubmitted by D. Avichezer in partial fulfillment of the requirements for a PhD degree from Bar-Ban University. The authors thank Miss Daniella Lustig for the skillful typing of the manuscript. This study was supported by the Mitzi-Dobrin Cancer ResearchF und, Bar-Ilan University.

Keywords

  • (Murine splenocyte, Pseudomonas aeruginosa)
  • Lymphocyte
  • Mitogenic lectin
  • PA-II lectin

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