P-LME polymer nanocapsules stimulate naïve macrophages and protect them from oxidative damage during controlled drug release

Anil K. Yamala; Vinod Nadella; Yitzhak Mastai; Hridayesh Prakash; Pradip Paik

doi:10.1002/app.48363

P-LME polymer nanocapsules stimulate naïve macrophages and protect them from oxidative damage during controlled drug release

Anil K. Yamala, Vinod Nadella, Yitzhak Mastai, Hridayesh Prakash, Pradip Paik

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Using polymer-based nanocapsules as novel drug delivery systems have gained significant importance. In this work, we present poly-(N-Acryloyl L-Leucine methyl ester [pLME]) nanocapsules with hollow core (pLME) of size approximately ~160 nm (dia.) synthesized for the first time through the miniemulsion approach. Our study reveals that pLME are biocompatible and immune stimulatory in nature on macrophages, which are decisive for host immunity. These nanocapsules are effective for encapsulating and sustainable release of drug (SNP; nitric oxide donor) at a high extent ~1.04 μM mg-. pLME also demonstrated their potential of stimulating naïve macrophages toward the M1 phenotype for extended period of time indicating their adjuvant activity on immune system. Our data also demonstrated their antioxidant potential toward H₂O₂-induced oxidative stress in macrophages. These results suggest pLME as an effective drug/vaccine delivery material with immune adjuvant and cytoprotective efficacy warranting its pharmacological application.

Original language	English
Article number	48363
Journal	Journal of Applied Polymer Science
Volume	137
Issue number	6
DOIs	https://doi.org/10.1002/app.48363
State	Published - 10 Feb 2020

Bibliographical note

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.

Funding

Authors acknowledge the Research support grants awarded by DST-Nanomission, India (Ref: SR/NM/NS-1005/2015) and Science and Engineering Research Board, India (Ref: EEQ/2016/000040), India to P. Paik and Research Grant (SR/S2/RJN/03/2012) awarded to H. Prakash by DST, India. Authors acknowledge the Research support grants awarded by DST‐Nanomission, India (Ref: SR/NM/NS‐1005/2015) and Science and Engineering Research Board, India (Ref: EEQ/2016/000040), India to P. Paik and Research Grant (SR/S2/RJN/03/2012) awarded to H. Prakash by DST, India.

Funders	Funder number
DST-Nanomission
DST‐Nanomission	SR/NM/NS‐1005/2015
Science and Engineering Research Board, India
Department of Science and Technology, Ministry of Science and Technology
Science and Engineering Research Board	EEQ/2016/000040, SR/S2/RJN/03/2012

Keywords

cytoprotective
immune stimulatory
pLME nanocapsules
sustained drug delivery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/app.48363

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abstract = "Using polymer-based nanocapsules as novel drug delivery systems have gained significant importance. In this work, we present poly-(N-Acryloyl L-Leucine methyl ester [pLME]) nanocapsules with hollow core (pLME) of size approximately ~160 nm (dia.) synthesized for the first time through the miniemulsion approach. Our study reveals that pLME are biocompatible and immune stimulatory in nature on macrophages, which are decisive for host immunity. These nanocapsules are effective for encapsulating and sustainable release of drug (SNP; nitric oxide donor) at a high extent ~1.04 μM mg-. pLME also demonstrated their potential of stimulating na{\"i}ve macrophages toward the M1 phenotype for extended period of time indicating their adjuvant activity on immune system. Our data also demonstrated their antioxidant potential toward H2O2-induced oxidative stress in macrophages. These results suggest pLME as an effective drug/vaccine delivery material with immune adjuvant and cytoprotective efficacy warranting its pharmacological application.",

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AU - Paik, Pradip

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P-LME polymer nanocapsules stimulate naïve macrophages and protect them from oxidative damage during controlled drug release

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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