Abstract
Tumor hypoxia is one of the hostile tumor microenvironment characteristics occurring in solid tumors. This feature is closely related to tumor progression and can negatively impair the effectiveness of cancer therapeutics. Recently, various strategies have been developed that enable efficient tumor oxygenation, not only enhancing treatment outcome of oxygen-consuming cancer therapeutics such as radiotherapy and photodynamic therapy, but also reversing the immunosuppressive tumor microenvironment to promote cancer immunotherapy. This review focuses on the latest progress in design and fabrication of innovative tumor-targeted oxygen nanoshuttles that attenuate tumor hypoxia and enhance cancer therapy. Future perspectives for clinical translation of tumor-targeted oxygen nanoshuttles will be further discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 239-250 |
| Number of pages | 12 |
| Journal | CCS Chemistry |
| Volume | 1 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 2019 |
Bibliographical note
Publisher Copyright:© 2019 Chinese Chemical Society.
Keywords
- Enhanced cancer treatment
- Oxygen nanoshuttles
- Tumor hypoxia
- Tumor microenvironment
- Tumor oxygenation
