Oxidation-reduction states of NADH in vivo: From animals to clinical use

Avraham Mayevsky, Britton Chance

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

Mitochondrial dysfunction is part of many pathological states in patients, such as sepsis or stroke. Presently, the monitoring of mitochondrial function in patients is extremely rare, even though NADH redox state is routinely measured in experimental animals. In this article, we describe the scientific backgrounds and practical use of mitochondrial NADH fluorescence measurement that was applied to patients in the past few years. In addition to NADH, we optically measured the microcirculatory blood flow and volume, as well as HbO2 oxygenation, from the same tissue area. The four detected parameters provide real time data on tissue viability, which is critical for patients monitoring.

Original languageEnglish
Pages (from-to)330-339
Number of pages10
JournalMitochondrion
Volume7
Issue number5
DOIs
StatePublished - Sep 2007

Bibliographical note

Funding Information:
This work was supported by the Israel Science Foundation Grant number 358/04 and by the Mina and Everard Goodman Faculty of Life Sciences Bar Ilan University, Israel.

Keywords

  • In vivo organ monitoring
  • Mitochondrial function
  • NADH redox state
  • Tissue blood flow
  • Tissue energy metabolism
  • Tissue viability

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