Oxidase-like Nanozyme Activity of Manganese Metal-Organic Framework Nanosheets for Colorimetric and Fluorescence Sensing of l-Cysteine

Ajit Kumar Singh; Kriti Bijalwan; Neha Kaushal; Anu Kumari; Avishek Saha; Arindam Indra

doi:10.1021/acsanm.3c01404

Oxidase-like Nanozyme Activity of Manganese Metal-Organic Framework Nanosheets for Colorimetric and Fluorescence Sensing of l-Cysteine

Ajit Kumar Singh, Kriti Bijalwan, Neha Kaushal, Anu Kumari, Avishek Saha, Arindam Indra

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The utilization of ultrathin Mn-metal-organic framework (Mn-UMOF) nanosheets for oxidase-like nanozyme activity has been demonstrated. The Mn-UMOF exhibited superior nanozyme activity to oxidize chromogenic TMB and ABTS than the bulk Mn-BMOF. Based on this fact, a platform for the colorimetric sensing of l-cysteine (l-cys) has been established over the detection of other amino acids and natural compounds such as urea and glucose. In addition, the Mn-UMOF has the capability of catalyzing the oxidation of amplex red to the fluorescent first oxidized product, which has been used to develop a fluorescence turn-off sensor for the selective sensing of l-cys.

Original language	English
Pages (from-to)	8036-8045
Number of pages	10
Journal	ACS Applied Nano Materials
Volume	6
Issue number	9
DOIs	https://doi.org/10.1021/acsanm.3c01404
State	Published - 12 May 2023
Externally published	Yes

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Publisher Copyright:
© 2023 American Chemical Society

Keywords

biosensor
fluorescence
nanozyme
oxidase activity
ultrathin metal−organic framework

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10.1021/acsanm.3c01404

Cite this

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title = "Oxidase-like Nanozyme Activity of Manganese Metal-Organic Framework Nanosheets for Colorimetric and Fluorescence Sensing of l-Cysteine",

abstract = "The utilization of ultrathin Mn-metal-organic framework (Mn-UMOF) nanosheets for oxidase-like nanozyme activity has been demonstrated. The Mn-UMOF exhibited superior nanozyme activity to oxidize chromogenic TMB and ABTS than the bulk Mn-BMOF. Based on this fact, a platform for the colorimetric sensing of l-cysteine (l-cys) has been established over the detection of other amino acids and natural compounds such as urea and glucose. In addition, the Mn-UMOF has the capability of catalyzing the oxidation of amplex red to the fluorescent first oxidized product, which has been used to develop a fluorescence turn-off sensor for the selective sensing of l-cys.",

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T1 - Oxidase-like Nanozyme Activity of Manganese Metal-Organic Framework Nanosheets for Colorimetric and Fluorescence Sensing of l-Cysteine

AU - Singh, Ajit Kumar

AU - Bijalwan, Kriti

AU - Kaushal, Neha

AU - Kumari, Anu

AU - Saha, Avishek

AU - Indra, Arindam

PY - 2023/5/12

Y1 - 2023/5/12

N2 - The utilization of ultrathin Mn-metal-organic framework (Mn-UMOF) nanosheets for oxidase-like nanozyme activity has been demonstrated. The Mn-UMOF exhibited superior nanozyme activity to oxidize chromogenic TMB and ABTS than the bulk Mn-BMOF. Based on this fact, a platform for the colorimetric sensing of l-cysteine (l-cys) has been established over the detection of other amino acids and natural compounds such as urea and glucose. In addition, the Mn-UMOF has the capability of catalyzing the oxidation of amplex red to the fluorescent first oxidized product, which has been used to develop a fluorescence turn-off sensor for the selective sensing of l-cys.

AB - The utilization of ultrathin Mn-metal-organic framework (Mn-UMOF) nanosheets for oxidase-like nanozyme activity has been demonstrated. The Mn-UMOF exhibited superior nanozyme activity to oxidize chromogenic TMB and ABTS than the bulk Mn-BMOF. Based on this fact, a platform for the colorimetric sensing of l-cysteine (l-cys) has been established over the detection of other amino acids and natural compounds such as urea and glucose. In addition, the Mn-UMOF has the capability of catalyzing the oxidation of amplex red to the fluorescent first oxidized product, which has been used to develop a fluorescence turn-off sensor for the selective sensing of l-cys.

KW - biosensor

KW - fluorescence

KW - nanozyme

KW - oxidase activity

KW - ultrathin metal−organic framework

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Oxidase-like Nanozyme Activity of Manganese Metal-Organic Framework Nanosheets for Colorimetric and Fluorescence Sensing of l-Cysteine

Abstract

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Keywords

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