Overview on natural hydrophilic polysaccharide polymers in drug delivery

Fatemeh Abedini, Mohammad Ebrahimi, Abbas Hemmati Roozbehani, Abraham J. Domb, Hossein Hosseinkhani

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations

Abstract

Nanotechnology is poised to make potentially revolutionary innovations in areas of biomedical science, such as gene therapy and drug therapy. A recently developed nanodelivery strategy involves the use of hydrophilic polymers as carriers of proteins and siRNA. By controlling the reaction conditions during polymer production, various degrees of anionic charge, cationic charge, and cross-linking can be added, thereby changing their capabilities as protein and nucleic acid carriers and promoting effective cell membrane permeation. The efficiency of a specific controlled-release polymeric system is determined in part by its unique physical and chemical properties and biodegradation rate. In this review, we will summarize recent progress in the ability to modify drug release of hydrophilic polymers nanoparticles.

Original languageEnglish
Pages (from-to)2564-2573
Number of pages10
JournalPolymers for Advanced Technologies
Volume29
Issue number10
DOIs
StatePublished - Oct 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 John Wiley & Sons, Ltd.

Keywords

  • alginate
  • chitosan
  • dextran-spermine
  • polymer
  • pullulan

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