Ovarian hyperstimulation syndrome: Prediction by number and size of preovulatory ovarian follicles

J. Blankstein; J. Shalev; T. Saadon; E. E. Kukia; J. Rabinovici; C. Pariente; B. Lunenfeld; D. M. Serr; S. Mashiach

doi:10.1016/s0015-0282(16)59109-2

Ovarian hyperstimulation syndrome: Prediction by number and size of preovulatory ovarian follicles

J. Blankstein, J. Shalev, T. Saadon, E. E. Kukia, J. Rabinovici, C. Pariente, B. Lunenfeld, D. M. Serr, S. Mashiach

Department of Chemistry

Sheba Medical Center at Tel Hashomer

Research output: Contribution to journal › Article › peer-review

196 Scopus citations

Abstract

Monitoring of human menopausal gonadotropin (hMG) treatment for induction of ovulation according to either preovulatory estrogen levels or the presence of a dominant ovarian follicle was found insufficient to prevent ovarian hyperstimulation syndrome (OHS). In 65 infertile patients treated with hMG and human chorionic gonadotropin (hCG), a possible correlation between the number and size of all ovarian follicles on the day of assumed ovulation and the occurrence of OHS was evaluated in order to assess the value of ultrasonography in predicting OHS. It was found that patients with OHS had significantly more follicles at the time of hCG than patients without OHS. Mild OHS was characterized by the presence of eight to nine follicles, 68.7% of which were of intermediate size (9 to 15 mm). In moderate to severe OHS 95% of the preovulatory follicles were <16mm, most of them (54.7%) <9 mm in diameter. It can be concluded that a specific preovulatory follicular configuration characterizes mild and severe hyperstimulation. This is important information before hCG administration and emphasizes the value of ovarian ultrasonography in predicting OHS.

Original language	English
Pages (from-to)	597-602
Number of pages	6
Journal	Fertility and Sterility
Volume	47
Issue number	4
DOIs	https://doi.org/10.1016/s0015-0282(16)59109-2
State	Published - Apr 1987

Bibliographical note

Funding Information:
Received March 3, 1986; revised and accepted December 22, 1986. *Supported in part by the Schreiber Foundation, Tel-Aviv University. tDepartment of Obstetrics and Gynecology, The Chaim Sheba Medical Center, and Sackler School of Medicine. :j:Reprint requests: Josef Blankstein, M.D., Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel. §Institute of Endocrinology, The Chaim Sheba Medical Center.

Funding

Received March 3, 1986; revised and accepted December 22, 1986. *Supported in part by the Schreiber Foundation, Tel-Aviv University. tDepartment of Obstetrics and Gynecology, The Chaim Sheba Medical Center, and Sackler School of Medicine. :j:Reprint requests: Josef Blankstein, M.D., Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel. §Institute of Endocrinology, The Chaim Sheba Medical Center.

Funders	Funder number
Schreiber Foundation
Tel Aviv University

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10.1016/s0015-0282(16)59109-2

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title = "Ovarian hyperstimulation syndrome: Prediction by number and size of preovulatory ovarian follicles",

abstract = "Monitoring of human menopausal gonadotropin (hMG) treatment for induction of ovulation according to either preovulatory estrogen levels or the presence of a dominant ovarian follicle was found insufficient to prevent ovarian hyperstimulation syndrome (OHS). In 65 infertile patients treated with hMG and human chorionic gonadotropin (hCG), a possible correlation between the number and size of all ovarian follicles on the day of assumed ovulation and the occurrence of OHS was evaluated in order to assess the value of ultrasonography in predicting OHS. It was found that patients with OHS had significantly more follicles at the time of hCG than patients without OHS. Mild OHS was characterized by the presence of eight to nine follicles, 68.7\% of which were of intermediate size (9 to 15 mm). In moderate to severe OHS 95\% of the preovulatory follicles were <16mm, most of them (54.7\%) <9 mm in diameter. It can be concluded that a specific preovulatory follicular configuration characterizes mild and severe hyperstimulation. This is important information before hCG administration and emphasizes the value of ovarian ultrasonography in predicting OHS.",

author = "J. Blankstein and J. Shalev and T. Saadon and Kukia, \{E. E.\} and J. Rabinovici and C. Pariente and B. Lunenfeld and Serr, \{D. M.\} and S. Mashiach",

note = "Funding Information: Received March 3, 1986; revised and accepted December 22, 1986. *Supported in part by the Schreiber Foundation, Tel-Aviv University. tDepartment of Obstetrics and Gynecology, The Chaim Sheba Medical Center, and Sackler School of Medicine. :j:Reprint requests: Josef Blankstein, M.D., Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel. §Institute of Endocrinology, The Chaim Sheba Medical Center.",

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AU - Rabinovici, J.

AU - Pariente, C.

AU - Lunenfeld, B.

AU - Serr, D. M.

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N2 - Monitoring of human menopausal gonadotropin (hMG) treatment for induction of ovulation according to either preovulatory estrogen levels or the presence of a dominant ovarian follicle was found insufficient to prevent ovarian hyperstimulation syndrome (OHS). In 65 infertile patients treated with hMG and human chorionic gonadotropin (hCG), a possible correlation between the number and size of all ovarian follicles on the day of assumed ovulation and the occurrence of OHS was evaluated in order to assess the value of ultrasonography in predicting OHS. It was found that patients with OHS had significantly more follicles at the time of hCG than patients without OHS. Mild OHS was characterized by the presence of eight to nine follicles, 68.7% of which were of intermediate size (9 to 15 mm). In moderate to severe OHS 95% of the preovulatory follicles were <16mm, most of them (54.7%) <9 mm in diameter. It can be concluded that a specific preovulatory follicular configuration characterizes mild and severe hyperstimulation. This is important information before hCG administration and emphasizes the value of ovarian ultrasonography in predicting OHS.

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Ovarian hyperstimulation syndrome: Prediction by number and size of preovulatory ovarian follicles

Abstract

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