TY - JOUR
T1 - Orbital mucosa-associated lymphoid tissue (MALT)-type lymphoma in a patient with relapsing polychondritis
AU - Lichauco, Juan Javier
AU - Lauer, Simeon
AU - Shigemitsu, Helen H.
AU - Bello, Jacqueline A.
AU - Bhattacharyya, Pritish Kumar
AU - Barland, Peter
AU - Putterman, Chaim
PY - 2001/7
Y1 - 2001/7
N2 - Relapsing polychondritis is characterized by recurrent inflammation of the cartilaginous tissues of the ears, nose, peripheral joints, and the tracheobronchial tree. The eye is also a frequent target organ in relapsing polychondritis, and proptosis is a well-recognized manifestation of eye involvement. Similar to other rheumatologic diseases, an association of relapsing polychondritis with malignancy has been reported. We describe a patient with relapsing polychondritis who presented with exophthalmos. When treatment directed toward control of her underlying disease was only partially effective, further investigation revealed that she had an orbital mucosa-associated lymphoid tissue (MALT)-type B cell lymphoma. We hypothesize that the lymphoma resulted from malignant transformation of the relapsing polychondritis - induced inflammatory pseudotumor and emphasize that neoplastic disease should be considered in the differential diagnosis in patients with relapsing polychondritis presenting with exophthalmos.
AB - Relapsing polychondritis is characterized by recurrent inflammation of the cartilaginous tissues of the ears, nose, peripheral joints, and the tracheobronchial tree. The eye is also a frequent target organ in relapsing polychondritis, and proptosis is a well-recognized manifestation of eye involvement. Similar to other rheumatologic diseases, an association of relapsing polychondritis with malignancy has been reported. We describe a patient with relapsing polychondritis who presented with exophthalmos. When treatment directed toward control of her underlying disease was only partially effective, further investigation revealed that she had an orbital mucosa-associated lymphoid tissue (MALT)-type B cell lymphoma. We hypothesize that the lymphoma resulted from malignant transformation of the relapsing polychondritis - induced inflammatory pseudotumor and emphasize that neoplastic disease should be considered in the differential diagnosis in patients with relapsing polychondritis presenting with exophthalmos.
UR - http://www.scopus.com/inward/record.url?scp=0034947087&partnerID=8YFLogxK
U2 - 10.1002/1529-0131(200107)44:7<1713::AID-ART296>3.0.CO;2-X
DO - 10.1002/1529-0131(200107)44:7<1713::AID-ART296>3.0.CO;2-X
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C2 - 11465724
AN - SCOPUS:0034947087
SN - 0004-3591
VL - 44
SP - 1713
EP - 1715
JO - Arthritis and Rheumatism
JF - Arthritis and Rheumatism
IS - 7
ER -