Oral lichen planus patients exhibit consistent chromosomal numerical aberrations: A follow-up analysis

Ran Yahalom; Noam Yarom; Tali Shani; Ninet Amariglio; Ilana Kaplan; Luba Trakhtenbrot; Abraham Hirshberg

doi:10.1002/hed.24086

Oral lichen planus patients exhibit consistent chromosomal numerical aberrations: A follow-up analysis

Ran Yahalom, Noam Yarom, Tali Shani, Ninet Amariglio, Ilana Kaplan, Luba Trakhtenbrot, Abraham Hirshberg

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background Oral lichen planus (OLP) carries an increased risk for malignant transformation with aneuploid cells (ACs) being found in brush samples of a quarter of patients with OLP. Methods Patients with OLP were followed and repeated brush samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) using centromeric probes for chromosomes 2 and 8. Results. Three patients with a high proportion of ACs developed oral cancer. Fifteen patients had ≥1% ACs (13 in affected sites and 2 in nonaffected sites), whereas only 2 of the 15 patients with <1% ACs in the first sample had ≥1% ACs in the second sample. A strong positive correlation between the results of the initial and repeated samples was found. Conclusion High proportion of ACs in brush samples from patients with OLP may imply an impending malignant transformation. As FISH analysis is consistent over time, it can be used to identify a subgroup of patients who would require close follow-up.

Original language	English
Pages (from-to)	E741-E746
Journal	Head and Neck
Volume	38
Early online date	20 Apr 2015
DOIs	https://doi.org/10.1002/hed.24086
State	Published - 1 Apr 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 Wiley Periodicals, Inc..

Funding

Contract grant sponsor: This study was supported by the Israel Science Foundation (grant number 935/12), and by the Israel Cancer Association (grant number 20100092).

Funders	Funder number
Israel Cancer Association	20100092
Israel Science Foundation	935/12

Keywords

aneuploidy
chromosomal instability
oral cancer
oral lichen planus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.24086

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title = "Oral lichen planus patients exhibit consistent chromosomal numerical aberrations: A follow-up analysis",

abstract = "Background Oral lichen planus (OLP) carries an increased risk for malignant transformation with aneuploid cells (ACs) being found in brush samples of a quarter of patients with OLP. Methods Patients with OLP were followed and repeated brush samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) using centromeric probes for chromosomes 2 and 8. Results. Three patients with a high proportion of ACs developed oral cancer. Fifteen patients had ≥1% ACs (13 in affected sites and 2 in nonaffected sites), whereas only 2 of the 15 patients with <1% ACs in the first sample had ≥1% ACs in the second sample. A strong positive correlation between the results of the initial and repeated samples was found. Conclusion High proportion of ACs in brush samples from patients with OLP may imply an impending malignant transformation. As FISH analysis is consistent over time, it can be used to identify a subgroup of patients who would require close follow-up.",

keywords = "aneuploidy, chromosomal instability, oral cancer, oral lichen planus",

author = "Ran Yahalom and Noam Yarom and Tali Shani and Ninet Amariglio and Ilana Kaplan and Luba Trakhtenbrot and Abraham Hirshberg",

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doi = "10.1002/hed.24086",

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T1 - Oral lichen planus patients exhibit consistent chromosomal numerical aberrations

T2 - A follow-up analysis

AU - Yahalom, Ran

AU - Yarom, Noam

AU - Shani, Tali

AU - Amariglio, Ninet

AU - Kaplan, Ilana

AU - Trakhtenbrot, Luba

AU - Hirshberg, Abraham

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background Oral lichen planus (OLP) carries an increased risk for malignant transformation with aneuploid cells (ACs) being found in brush samples of a quarter of patients with OLP. Methods Patients with OLP were followed and repeated brush samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) using centromeric probes for chromosomes 2 and 8. Results. Three patients with a high proportion of ACs developed oral cancer. Fifteen patients had ≥1% ACs (13 in affected sites and 2 in nonaffected sites), whereas only 2 of the 15 patients with <1% ACs in the first sample had ≥1% ACs in the second sample. A strong positive correlation between the results of the initial and repeated samples was found. Conclusion High proportion of ACs in brush samples from patients with OLP may imply an impending malignant transformation. As FISH analysis is consistent over time, it can be used to identify a subgroup of patients who would require close follow-up.

AB - Background Oral lichen planus (OLP) carries an increased risk for malignant transformation with aneuploid cells (ACs) being found in brush samples of a quarter of patients with OLP. Methods Patients with OLP were followed and repeated brush samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) using centromeric probes for chromosomes 2 and 8. Results. Three patients with a high proportion of ACs developed oral cancer. Fifteen patients had ≥1% ACs (13 in affected sites and 2 in nonaffected sites), whereas only 2 of the 15 patients with <1% ACs in the first sample had ≥1% ACs in the second sample. A strong positive correlation between the results of the initial and repeated samples was found. Conclusion High proportion of ACs in brush samples from patients with OLP may imply an impending malignant transformation. As FISH analysis is consistent over time, it can be used to identify a subgroup of patients who would require close follow-up.

KW - aneuploidy

KW - chromosomal instability

KW - oral cancer

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ER -

Oral lichen planus patients exhibit consistent chromosomal numerical aberrations: A follow-up analysis

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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