Oral co-administration of soy-derived extracts with alcohol or with sugar-sweetened beverages exerts liver and sugar protective effects

Tawfik Khoury, Devorah Rotnemer-Golinkin, Yehudit Shabat, Lidya Zolotarovya, Yaron Ilan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background and Aims: Both alcoholic drinks and high sugar-containing soft drinks cause major health problems worldwide. Oral administration of OS and M1 soy-derived extracts has been shown to alleviate liver injury in animal models. The aim of the present study was to determine the liver-and sugar-protective effect of OS and M1 soy-derived extracts when added to alcohol and sugar-enriched drinks. Methods: Mice were treated with alcohol or high sugarcontaining drinks, with and without administration of a combination of OS and M1 soy extracts. Mice were observed for the effects on liver injury, glucose metabolism, and the immune system. Results: Co-administration of the soy extracts OS and M1 significantly alleviated the liver injury induced by acute alcohol, as evidenced by decreased liver enzymes. These beneficial effects were associated with promotion of subsets of regulatory T lymphocytes and with a trend towards a pro-inflammatory to an anti-inflammatory cytokine shift. Co-administration of OS M1 soy extracts with sugar-sweetened beverages significantly alleviated the increases in serum sugar levels. Conclusion: OS and M1 extracts exert a synergistic hepato-and glucose-protective effect in models of alcohol-induced liver damage and soft drinks-associated increases in serum glucose. These extracts may provide a solution to the two pressing health problems.

Original languageEnglish
Pages (from-to)208-215
Number of pages8
JournalJournal of Clinical and Translational Hepatology
Volume5
Issue number3
DOIs
StatePublished - 28 Sep 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Authors.

Funding

The study was supported in part by the Ruth Epstein Foundation.

FundersFunder number
Ruth Epstein Foundation

    Keywords

    • Alcoholic liver disease
    • Soda drinks
    • Soy
    • T regulatory cells

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