Abstract
The rationale design aimed at the enhancement of cationic lipid mediated gene transfer is discussed. These improvements are based on the straight evaluation of the structure-activity relationship and on the introduction of new structures. Much attention have been given to the supramolecular structures of the lipid/DNA complexes, to the effect of serum on gene transfer and to the intracellular trafficking of the lipoplexes. Finally new avenue using reducible cationic lipids has been discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 95-106 |
| Number of pages | 12 |
| Journal | Journal of Liposome Research |
| Volume | 12 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 2002 |
Bibliographical note
Funding Information:This work is supported by the Centre National de la Recherche Scientifique, Aventis-Gencell, the Association pour la Recherche sur le Cancer and the Ministére de la Recherche.
Funding
This work is supported by the Centre National de la Recherche Scientifique, Aventis-Gencell, the Association pour la Recherche sur le Cancer and the Ministére de la Recherche.
| Funders |
|---|
| Ministére de la Recherche |
| Association pour la Recherche sur le Cancer |
| Centre National de la Recherche Scientifique |
Keywords
- Cationic Lipids
- Gene transfer
- Physico-chemistry
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