Optical-resolution photoacoustic endomicroscopy in vivo

Joon Mo Yang, Chiye Li, Ruimin Chen, Bin Rao, Junjie Yao, Cheng Hung Yeh, Amos Danielli, Konstantin Maslov, Qifa Zhou, K. Kirk Shung, Lihong V. Wang

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Optical-resolution photoacoustic microscopy (OR-PAM) has become a major experimental tool of photoacoustic tomography, with unique imaging capabilities for various biological applications. However, conventional imaging systems are all table-top embodiments, which preclude their use in internal organs. In this study, by applying the ORPAM concept to our recently developed endoscopic technique, called photoacoustic endoscopy (PAE), we created an optical-resolution photoacoustic endomicroscopy (OR-PAEM) system, which enables internal organ imaging with a much finer resolution than conventional acousticresolution PAE systems. OR-PAEM has potential preclinical and clinical applications using either endogenous or exogenous contrast agents.

Original languageEnglish
Pages (from-to)918-932
Number of pages15
JournalBiomedical Optics Express
Issue number3
StatePublished - 2015

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Publisher Copyright:
© 2015 Optical Society of America.


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