Optical detection of single molecules in nanofluidic chips

Gea O.F. Parikesit; Vladimir G. Kutchoukov; Wim Van Oel; Guus L. Lung; Andre Bossche; Ian T. Young; Yuval Garini

doi:10.1117/12.559386

Optical detection of single molecules in nanofluidic chips

Gea O.F. Parikesit, Vladimir G. Kutchoukov, Wim Van Oel, Guus L. Lung, Andre Bossche, Ian T. Young, Yuval Garini

Delft University of Technology

Research output: Contribution to journal › Conference article › peer-review

3 Scopus citations

Abstract

We present the latest progress on a novel technology for detecting and manipulating solution of single molecules in nanofluidic channels. This paper explains the design and fabrication of nanofluidic chip and its interface, molecule manipulation technique being used, and the optical detection method employed. Single molecule detections are performed using optical imaging as well as metal microelectrodes. The ultimate goal is to get high spatial and spectral resolutions that can lead to molecular identification.

Original language	English
Article number	18
Pages (from-to)	109-116
Number of pages	8
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5515
DOIs	https://doi.org/10.1117/12.559386
State	Published - 2004
Externally published	Yes
Event	Nanoengineering: Fabrication, Properties, Optics, and Devices - Denver, CO, United States Duration: 4 Aug 2004 → 6 Aug 2004

Keywords

Lab on a chip
Nanofluidics
Optical detection
Single molecules

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10.1117/12.559386

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abstract = "We present the latest progress on a novel technology for detecting and manipulating solution of single molecules in nanofluidic channels. This paper explains the design and fabrication of nanofluidic chip and its interface, molecule manipulation technique being used, and the optical detection method employed. Single molecule detections are performed using optical imaging as well as metal microelectrodes. The ultimate goal is to get high spatial and spectral resolutions that can lead to molecular identification.",

keywords = "Lab on a chip, Nanofluidics, Optical detection, Single molecules",

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AU - Parikesit, Gea O.F.

AU - Kutchoukov, Vladimir G.

AU - Van Oel, Wim

AU - Lung, Guus L.

AU - Bossche, Andre

AU - Young, Ian T.

AU - Garini, Yuval

PY - 2004

Y1 - 2004

N2 - We present the latest progress on a novel technology for detecting and manipulating solution of single molecules in nanofluidic channels. This paper explains the design and fabrication of nanofluidic chip and its interface, molecule manipulation technique being used, and the optical detection method employed. Single molecule detections are performed using optical imaging as well as metal microelectrodes. The ultimate goal is to get high spatial and spectral resolutions that can lead to molecular identification.

AB - We present the latest progress on a novel technology for detecting and manipulating solution of single molecules in nanofluidic channels. This paper explains the design and fabrication of nanofluidic chip and its interface, molecule manipulation technique being used, and the optical detection method employed. Single molecule detections are performed using optical imaging as well as metal microelectrodes. The ultimate goal is to get high spatial and spectral resolutions that can lead to molecular identification.

KW - Lab on a chip

KW - Nanofluidics

KW - Optical detection

KW - Single molecules

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Y2 - 4 August 2004 through 6 August 2004

ER -

Optical detection of single molecules in nanofluidic chips

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Keywords

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