Optical detection of electrokinetically manipulated single molecules in a nanofluidic chip

Gea O.F. Parikesit, Vladimir G. Kutchoukov, Andre Bossche, Ian T. Young, Yuval Garini

Research output: Contribution to journalConference articlepeer-review

5 Scopus citations


We report on the progress of a novel nanofluidic device for detecting and manipulating single molecules in solution. This paper discusses the development of an earlier proposed molecule separation method, where electrokinetic forces separate different molecules based on their masses and charges. Optical imaging using confocal microscopy is applied to perform the detection of the single molecules. Potential applications of this device will be assessed. This research aims for the high spatial and spectral resolutions, both in manipulation and detection, which can lead to molecular identification.

Original languageEnglish
Article number18
Pages (from-to)133-141
Number of pages9
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2005
Externally publishedYes
EventMicrofluidics, BioMEMS, and Medical Microsystems III - San Jose, CA, United States
Duration: 24 Jan 200526 Jan 2005


  • Lab on a chip
  • Molecular identification
  • Nanofluidics
  • Optical detection
  • Single molecules


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