Abstract
Ontogenetic differences in seizure thresholds to pentylenetetrazol (PTZ) were examined in young, developing rats (ages: 10, 18, 28, and 60 days). A subconvulsive dose of PTZ (15 mg/kg IP) was administered every 10 min and the occurrence of partial and full (clonic tonic) seizures was noted. Ten day old pups displayed complete seizures more rapidly than any of the other groups (p < .01) without any behavioral indication of going through the partial stages. Among 18 day old pups the development of early seizure stages was followed rapidly by the full seizure, while in the weaned groups the early seizure stages tended to persist much longer before the appearance of the full generalized convulsion. The preweanling rat's immature brain seems less able to suppress PTZ induced generalized convulsions compared to the brain of the older rats.
| Original language | English |
|---|---|
| Pages (from-to) | 629-631 |
| Number of pages | 3 |
| Journal | Physiology and Behavior |
| Volume | 57 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1995 |
Bibliographical note
Funding Information:This project was completed while David I. Mostofsky (Boston University) was supported by a Senior Fulbright Award to Bar Ilan University. Aron Weller was supported by the Yigal Alon Fund and a Bar Ilan University Internal Research Grant. The authors thank Prof. S. Yehuda for his valuable assistance.
Funding
This project was completed while David I. Mostofsky (Boston University) was supported by a Senior Fulbright Award to Bar Ilan University. Aron Weller was supported by the Yigal Alon Fund and a Bar Ilan University Internal Research Grant. The authors thank Prof. S. Yehuda for his valuable assistance.
| Funders | Funder number |
|---|---|
| Bar Ilan University | |
| Yigal Alon Fund |
Keywords
- Convulsions
- Development
- Ontogeny
- Pentylenetetrazol (PTZ)
- Preweanling rats
- Seizures