TY - JOUR
T1 - One-pot synthesis of novel antiproliferative 9-aminoacridines
AU - Gellerman, Gary
AU - Waintraub, Sagiv
AU - Albeck, Amnon
AU - Gaisin, Vladimir
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/8
Y1 - 2011/8
N2 - Highly efficient one-pot syntheses of antiproliferative 9-aminoacridine (9-AA) derivatives are described. Simple SNAr and addition/elimination reactions, using readily accessible starting materials, give a fast entry to novel 9-(pyridylamino)acridines, 9-(pyrimidinylamino) acridines and potential "dual-function" bioreductive 9-(acridinylamino)quinone intercalators. The synthetic routes reported in this work are general and readily applicable, significantly expanding the range and scope of potential 9-AA anticancer candidates.
AB - Highly efficient one-pot syntheses of antiproliferative 9-aminoacridine (9-AA) derivatives are described. Simple SNAr and addition/elimination reactions, using readily accessible starting materials, give a fast entry to novel 9-(pyridylamino)acridines, 9-(pyrimidinylamino) acridines and potential "dual-function" bioreductive 9-(acridinylamino)quinone intercalators. The synthetic routes reported in this work are general and readily applicable, significantly expanding the range and scope of potential 9-AA anticancer candidates.
KW - 9-Aminoacridine
KW - Nucleophilic substitution
KW - Quinones
KW - addition-elimination
KW - anticancer
KW - one-pot synthesis
UR - http://www.scopus.com/inward/record.url?scp=79960566363&partnerID=8YFLogxK
U2 - 10.1002/ejoc.201100133
DO - 10.1002/ejoc.201100133
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SN - 1434-193X
SP - 4176
EP - 4182
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
IS - 22
ER -